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Merck
CN

V-002

Verapamil hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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经验公式(希尔记法):
C27H38N2O4·HCl
化学文摘社编号:
分子量:
491.06
NACRES:
NA.24
UNSPSC Code:
41116107
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产品名称

Verapamil hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

InChI

1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H

InChI key

DOQPXTMNIUCOSY-UHFFFAOYSA-N

SMILES string

Cl.COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

2-8°C

Quality Level

Gene Information

General description

Verapamil, a phenylalkylamine analog, is used to treat high blood pressure and angina. This analytical reference standard is applicable for use as starting material in calibrators or controls for verapamil testing methods by LC-MS/MS or GC-MS. A calcium channel blocker, verapamil is sold under trade names Calan® and Covera-HS®.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Calan is a registered trademark of G.D. Searle & Co.
Covera-HS is a registered trademark of G.D. Searle, LLC
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

存储类别

3 - Flammable liquids

wgk

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

法规信息

危险化学品
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Avi Stein et al.
Harefuah, 151(11), 638-640 (2013-02-02)
Peyronie's disease may be idiopatic or secondary to sexual intercourse. Medical treatment includes vitamin E, colchicine and tamoxifen, which provide a very limited solution. Lately, intralesional injection of verapamil and other substances have achieved a reasonable effect. The best cosmetic
Gargey B Yagnik et al.
Journal of mass spectrometry : JMS, 48(1), 100-104 (2013-01-11)
We have previously developed in-parallel data acquisition of orbitrap mass spectrometry (MS) and ion trap MS and/or MS/MS scans for matrix-assisted laser desorption/ionization MS imaging (MSI) to obtain rich chemical information in less data acquisition time. In the present study
Carsten Stengaard et al.
Ugeskrift for laeger, 175(1-2), 54-55 (2013-01-12)
Verapamil administered intravenously is recommended as a first-line therapy in patients with supraventricular tachycardia. However, these patients may suffer from tachycardia-induced heart failure and particular caution is needed before prescription of verapamil in these cases. We present a case of
Jian-Min Shen et al.
Pharmacological research, 70(1), 102-115 (2013-02-05)
In this paper we give a method of integrated treatment for cancer and drug-induced complications in the process of cancer therapy through dual-drug delivery system (DDDS). Two hydrophilic drugs, doxorubicin (an antitumor drug) and verapamil (an antiangiocardiopathy drug) combined preliminarily
Matylda Resztak et al.
Acta poloniae pharmaceutica, 70(3), 395-401 (2013-06-14)
A stereospecific capillary zone electrophoresis (CZE) method was developed for the determination of verapamil (VER) and its main metabolite norverapamil (NOR) in human plasma. Optimal temperature, cyclodextrin selectors (CDs), pH of background electrolyte (BGE) and voltage were established to obtain

实验方案

LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18

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