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安全信息

T-074

Supelco

3,3′,5-三碘-L-甲状腺原氨酸（T3） 溶液

100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

别名:

3,3′,5-三碘代-L-甲状腺原氨酸, O-(4-羟基-3-碘苯基)-3,5-二碘代-L-酪氨酸, T3, 碘噻罗宁

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About This Item

经验公式（希尔记法）:
C15H12I3NO4
CAS号:
6893-02-3
分子量:
650.97
Beilstein:
2710227
MDL编号:
MFCD00002593
UNSPSC代码:
41116107
PubChem化学物质编号:
329826618
NACRES:
NA.24

等级

certified reference material

质量水平

300

形式

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

浓度

100 μg/mL in methanol with 0.1N NH3

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

234-238 °C (lit.)

应用

clinical testing
clinical testing

格式

single component solution

储存温度

−20°C

SMILES字符串

N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1

InChI key

AUYYCJSJGJYCDS-LBPRGKRZSA-N

基因信息

human ... THRA(7067) , THRB(7068)

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相关类别

一般描述

该认证加标溶液® 适合用作制备线性标准品、校准品和对照品的起始物料，用于通过 LC-MS/MS 法检测甲状腺激素。

3,3′,5-三碘-L-甲状腺原氨酸（T3）是一种甲状腺激素，也是 l -甲状腺素（T4）的活性形式，由 I 型或 II 型脱碘酶形成。它支持各种生理功能，如氧气消耗、碳水化合物代谢、蛋白质合成和神经发育。通过 LC-MS/MS 测量游离和总 T3 血清水平，以确定由过量 T3 引起的甲状腺功能亢进症。

应用

该认证标准物质（CRM）还可作如下用途：

  • 通过同位素稀释液相色谱-四极杆飞行时间质谱法（LC-Q-TOF-MS）对胎盘样品中的七种甲状腺激素进行多残留测定
  • 通过固相萃取（SPE）和超高效液相色谱-电喷雾电离-串联质谱（UPLC-ESI/MS/MS）分析斑马鱼幼体中的 5 种甲状腺激素（兆分之一）
  • 通过超滤-高效液相色谱（HPLC）-串联质谱（MS/MS）法同时分析牛血清样品中的 6 种游离甲状腺激素
  • 通过同位素稀释纳米超高效液相色谱–四极杆飞行时间质谱（LC-Q-TOF-MS）测定小鼠组织样品中的 6 种甲状腺激素
  • 使用液相色谱-串联质谱法（LC-MS/MS）测定大鼠血清样品中的三碘甲状腺原氨酸和甲状腺素

特点和优势

  • 完全符合 ISO/IEC 17025 和 ISO 17034 认证
  • 附综合分析证书（CoA），包括稳定性、均匀性、浓度准确性、不确定性和可追溯性数据
  • 通过实时稳定性研究严格测试，以确保准确性和保质期
  • 使用合格的精密天平进行重量准备，以确保最小不确定性
  • 氩气环境下火焰密封，装入安瓿以便长期保存
  • 提供方便的 DEA 豁免格式，以提高实验室效率

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes,Central nervous system

WGK

WGK 2

闪点(°F)

49.5 °F

闪点(°C)

9.7 °C

法规信息

危险化学品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Vasiliki Michopoulos et al.
Fertility and sterility, 99(7), 2084-2091 (2013-03-20)
To determine whether cognitive behavior therapy (CBT), which we had shown in a previous study to restore ovarian function in women with functional hypothalamic amenorrhea (FHA), could also ameliorate hypercortisolemia and improve other neuroendocrine and metabolic concomitants of in FHA.
Susana B Bravo et al.
The Journal of clinical endocrinology and metabolism, 98(6), 2431-2441 (2013-03-30)
Mechanisms of thyroid physiology and cancer are principally studied in follicular cell lines. However, human thyroid cancer lines were found to be heavily contaminated by other sources, and only one supposedly normal-thyroid cell line, immortalized with SV40 antigen, is available.
Pragya Sharma et al.
The Journal of biological chemistry, 288(23), 16321-16333 (2013-05-01)
Secretory phospholipase A2 group IIa (PLA2g2a) is associated with inflammation, hyperlipidemia, and atherogenesis. Transcription of the PLA2g2a gene is induced by multiple cytokines. Here, we report the surprising observation that thyroid hormone (T3) inhibited PLA2g2a gene expression in human and
V N Buriak et al.
Likars'ka sprava, (5)(5), 58-63 (2013-03-29)
The paper deals with etiopathogenetic and clinical peculiarities, and also therapeutic methods during the pathological processes in the thyroid system in the childhood. The most common of these processes is the diffuse nontoxic goiter, which results in abnormality of metabolic
Min Kyong Moon et al.
European journal of endocrinology, 168(6), 805-810 (2013-03-21)
Body adiposity, especially ectopic fat accumulation, has a range of metabolic and cardiovascular effects. This study aimed to investigate whether thyroid function is associated with various regional fat quantities in euthyroid subjects. A total of 100 euthyroid men (free triiodothyronine
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实验方案

Online SPE/LC-MS Method for the Rapid Analysis of Thyroid Hormones in Plasma

Determination of the thyroid hormones T4, T3 and rT3 from plasma using an Ascentis Express RP-Amide cartridge to trap the analytes, and a Phenyl-Hexyl column to resolve them.

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