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Merck
CN
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文件

安全信息

P-108

Supelco

Posaconazole-D4 solution

1.0 mg/mL in methanol, certified reference material, Cerilliant®

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经验公式（希尔记法）:
C37H38D4F2N8O4
CAS号:
1133712-26-1
分子量:
704.80
MDL编号:
MFCD28899339
UNSPSC代码:
41116107
PubChem化学物质编号:
329820071
NACRES:
NA.24

等级

certified reference material

质量水平

300

形式

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

浓度

1.0 mg/mL in methanol

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

格式

single component solution

储存温度

−20°C

SMILES字符串

FC1=CC(F)=CC=C1[C@]2(CN3C=NC=N3)OC[C@@H](COC4=CC=C(N5CCN(C6=C([2H])C([2H])=C(N7C=NN([C@@H](CC)[C@@H](O)C)C7=O)C([2H])=C6[2H])CC5)C=C4)C2

InChI

1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1/i5D,6D,7D,8D

InChI key

RAGOYPUPXAKGKH-YWOVKAAPSA-N

相关类别

一般描述

This stable-labeled internal standard is suitable for quantification of posaconazole levels in blood, serum, or plasma by HPLC or LC-MS/MS. The antifungal posaconazole is used to treat invasive and systemic fungal infections. As a result of significant drug interactions, therapeutic drug monitoring of posaconazole is recommended when administered with protease inhibitors (PIs) or non-nucleoside reverse transcriptase inhibitors (NNRTIs).

应用


  • Quantification of posaconazole in human plasma: A liquid chromatography-mass spectrometry method was developed for the quantification of posaconazole, utilizing Posaconazole-D4 as an internal standard. This method was applied to pharmacokinetic studies following single-dose administration in both fasted and high-fat meal states, highlighting its utility in assessing drug bioavailability and metabolism (Xu et al., 2013).

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes

WGK

WGK 2

法规信息

危险化学品

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