推荐产品
等级
certified reference material
质量水平
形式
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
1.0 mg/mL in methanol (as free base)
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
clinical testing
格式
single component solution
储存温度
2-8°C
SMILES字符串
Cl.CNCCCN1c2ccccc2CCc3ccccc13
InChI
1S/C18H22N2.ClH/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20;/h2-5,7-10,19H,6,11-14H2,1H3;1H
InChI key
XAEWZDYWZHIUCT-UHFFFAOYSA-N
基因信息
human ... SLC6A2(6530)
一般描述
A Certified Solution Standard suitable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications from forensic analysis and clinical toxicology to urine drug testing. Desipramine is a tricyclic antidepressant (TCA) sold under the brand names Norpramin® and Pertofrane. This TCA drug is also a primary active metabolite of imipramine.
应用
- Pharmacological Treatments for Localized Provoked Vulvodynia: Reviews current pharmacological treatments, including tricyclic antidepressants like desipramine hydrochloride, emphasizing their role in managing chronic pain conditions, crucial for ongoing research in neuropharmacology and clinical practice (Bajzak et al., 2023).
- Desipramine induces anti-inflammatory dorsal root ganglion transcriptional signatures: Highlights the use of desipramine hydrochloride in neurobiological research, specifically its effects on inflammatory responses in nerve injury models, underscoring its significance in neuropharmacological studies (Serafini et al., 2024).
- Effect of lipid emulsion on neuropsychiatric drug-induced toxicity: Discusses the therapeutic potential of lipid emulsions in managing toxicity caused by drugs, including desipramine hydrochloride, which is essential for improving safety profiles in clinical settings (Hwang and Sohn, 2024).
- Sustainable beeswax modified cellulose paper for the determination of tricyclic antidepressants: Researches innovative methods for detecting tricyclic antidepressants like desipramine hydrochloride in biofluids, pivotal for advancing forensic and clinical toxicology (González-Bermúdez et al., 2024).
- Sleep-wake dependent hippocampal regulation of fear memory: Although indirectly related, this study forms part of the broader context of neurological research where desipramine hydrochloride could be used to modulate neurochemical pathways, relevant for understanding sleep-related memory processes (Wen et al., 2024).
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Norpramin is a registered trademark of Aventisub II Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes
WGK
WGK 1
闪点(°F)
closed cup
闪点(°C)
closed cup
法规信息
危险化学品
Richard M O'Connor et al.
Pharmacology, biochemistry, and behavior, 103(3), 561-567 (2012-10-13)
The neurotransmitter glutamate is increasingly being implicated as playing a role in the molecular pathology underlying depression. The group III family of metabotropic glutamate (mGlu) receptors (mGlu(4,) mGlu(7) and mGlu(8) receptors) remains the most poorly investigated of all glutamate receptors
O F O'Leary et al.
Neuroscience, 228, 36-46 (2012-10-17)
Approximately 50% of patients with a major depressive episode fail to achieve remission with first-line antidepressant treatments. Second-line treatment strategies for such patients include lithium augmentation of antidepressants, particularly with tricyclic antidepressants. The neurobiological mechanisms underlying the therapeutic effects of
Maria Stratinaki et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(20), 8254-8259 (2013-05-01)
Regulator of G protein signaling 4 (Rgs4) is a signal transduction protein that controls the function of monoamine, opiate, muscarinic, and other G protein-coupled receptors via interactions with Gα subunits. Rgs4 is expressed in several brain regions involved in mood
Thomas M Polasek et al.
British journal of clinical pharmacology, 75(4), 1019-1028 (2012-08-29)
To determine the effect of increasing adult age on predicted metabolic drug clearance. Predicted metabolic drug clearances (CLPT ) were determined using in vitro-in vivo extrapolation coupled with physiological-based pharmacokinetic modelling and simulation (IVIVE-PBPK) in Simcyp®. Simulations were conducted using
Aaron Kucinski et al.
Behavioural brain research, 282, 155-164 (2015-01-18)
Falls in patients with Parkinson's disease (PD) are a major and levodopa-unresponsive source of morbidity. We previously described an animal model of falls resulting from impairments in attentional-motor interactions. Reproducing the multisystem dopaminergic-cholinergic cell loss in patients with a history
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