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安全信息

D-070

Supelco

N-Desmethylolanzapine-d8 dihydrochloride solution

100 μg/mL in acetonitrile: water (1:1) (as free base), ampule of 1 mL, certified reference material, Cerilliant®

别名:

N-Desmethylolanzapine-D8 dihydrochloride solution

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About This Item

经验公式（希尔记法）:
C16D8H10N4S · H2Cl2
分子量:
379.38
UNSPSC代码:
41116107
NACRES:
NA.24

等级

certified reference material

质量水平

300

表单

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

浓度

100 μg/mL in acetonitrile: water (1:1) (as free base)

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

clinical testing

包装形式

single component solution

储存温度

2-8°C

相关类别

一般描述

A stable-labeled internal standard for use in LC/MS or GC/MS applications including clinical toxicology analysis, therapeutic drug monitoring, or isotope dilution methods. Desmethylolanzapine is the primary metabolite of olanzapine, marketed as the atypical antipsychotic Zyprexa® for the treatment of schizophrenia and bipolar disorder.

应用


  • Monitoring Metabolic Parameters in Schizophrenia: A study utilized plasma levels of olanzapine and its metabolite, N-desmethyl-olanzapine, to monitor metabolic parameters in patients with schizophrenia, providing a critical link between antipsychotic drug concentrations and metabolic health. This research supports the use of these biomarkers in clinical settings to optimize therapeutic strategies and manage side effects (Lu et al., 2018).

  • Evaluating Clinical Efficacy in Schizophrenia: Another significant study applied plasma levels of olanzapine and N-desmethyl-olanzapine to assess clinical efficacy in schizophrenia patients. By correlating drug levels with therapeutic outcomes, this approach aids in personalized medicine, ensuring patients receive optimal dosages for effective treatment (Lu et al., 2016).

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Zyprexa is a registered trademark of Eli Lilly and Co.

象形图

FlameExclamation mark
GHS02,GHS07

警示用语：

Danger

危险声明

H225,H302,H319

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

储存分类代码

3 - Flammable liquids

WGK

WGK 2

闪点(°F)

55.4 °F - closed cup

闪点(°C)

13 °C - closed cup

法规信息

危险化学品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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