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经验公式（希尔记法）:
C36H51BF2N2O
化学文摘社编号:
分子量:
576.61
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
产品名称
TopFluor™胆固醇, Avanti Research™ - A Croda Brand
description
23-(dipyrrometheneboron difluoride)-24-norcholesterol
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (810255P-1mg)
pkg of 1 × 10 mg (810255P-10mg)
pkg of 1 × 5 mg (810255P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
Application
TOPFLUOR™适用于:
- 胆固醇摄取测定
- 在活细胞实验中用于BODIPY胆固醇标记
- 通过聚乙烯醇（PVA）辅助的脂质溶胀形成巨大的Janus脂质体
Biochem/physiol Actions
BODIPY标记的胆固醇具有与天然胆固醇相似的特性。它可充当活细胞的胆固醇标志物，并有助于运输细胞内的胆固醇。它也可能有助于指示脂质储存疾病。
General description
附着在BODIPY上的生物分子在可见光下很容易被吸收。它导致更大的荧光量子产率。它具有很高的光稳定性，并且对极性和pH的变化不太敏感。
Packaging
5 mL棕色玻璃螺旋盖小瓶（810255P-10mg）
5 mL棕色玻璃螺旋盖小瓶（810255P-1mg）
5 mL棕色玻璃螺旋盖小瓶（810255P-5mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
Maarit Hölttä-Vuori et al.
Traffic (Copenhagen, Denmark), 9(11), 1839-1849 (2008-07-24)
Analysis of sterol distribution and transport in living cells has been hampered by the lack of bright, photostable fluorescent sterol derivatives that closely resemble cholesterol. In this study, we employed atomistic simulations and experiments to characterize a cholesterol compound with
Frederik W Lund et al.
BMC biophysics, 5, 20-20 (2012-10-20)
Cholesterol is an important membrane component, but our knowledge about its transport in cells is sparse. Previous imaging studies using dehydroergosterol (DHE), an intrinsically fluorescent sterol from yeast, have established that vesicular and non-vesicular transport modes contribute to sterol trafficking
Sandhya Sankaranarayanan et al.
Journal of lipid research, 52(12), 2332-2340 (2011-10-01)
Studies have shown a negative association between cellular cholesterol efflux and coronary artery disease (CAD). Standard protocol for quantitating cholesterol efflux involves labeling cells with [(3)H]cholesterol and measuring release of the labeled sterol. Using [(3)H]cholesterol is not ideal for the
Florly S Ariola et al.
Biophysical journal, 96(7), 2696-2708 (2009-04-08)
Cholesterol-rich, liquid-ordered (L(o)) domains are believed to be biologically relevant, and yet detailed knowledge about them, especially in live cells under physiological conditions, is elusive. Although these domains have been observed in model membranes, understanding cholesterol-lipid interactions at the molecular
James E Shaw et al.
Journal of structural biology, 155(3), 458-469 (2006-08-08)
Elucidating the role that charged membrane proteins play in determining cell membrane structure and dynamics is an area of active study. We have applied in situ correlated atomic force and confocal microscopies to characterize the interaction of the NAP-22 peptide
商品
Explore full-spectrum fluorophores, fluorescent lipids, and probes for imaging, membrane studies, and labeling with TopFluor™, squaraines, and more.
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