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描述
23-(dipyrrometheneboron difluoride)-24-norcholesterol
方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 1 mg (810255P-1mg)
pkg of 1 × 10 mg (810255P-10mg)
pkg of 1 × 5 mg (810255P-5mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
运输
dry ice
储存温度
−20°C
一般描述
附着在BODIPY上的生物分子在可见光下很容易被吸收。它导致更大的荧光量子产率。它具有很高的光稳定性，并且对极性和pH的变化不太敏感。
应用
TOPFLUOR™适用于:
- 胆固醇摄取测定
- 在活细胞实验中用于BODIPY胆固醇标记
- 通过聚乙烯醇（PVA）辅助的脂质溶胀形成巨大的Janus脂质体
生化/生理作用
BODIPY标记的胆固醇具有与天然胆固醇相似的特性。它可充当活细胞的胆固醇标志物，并有助于运输细胞内的胆固醇。它也可能有助于指示脂质储存疾病。
包装
5 mL棕色玻璃螺旋盖小瓶（810255P-10mg）
5 mL棕色玻璃螺旋盖小瓶（810255P-1mg）
5 mL棕色玻璃螺旋盖小瓶（810255P-5mg）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
Florly S Ariola et al.
Biophysical journal, 96(7), 2696-2708 (2009-04-08)
Cholesterol-rich, liquid-ordered (L(o)) domains are believed to be biologically relevant, and yet detailed knowledge about them, especially in live cells under physiological conditions, is elusive. Although these domains have been observed in model membranes, understanding cholesterol-lipid interactions at the molecular
Sandhya Sankaranarayanan et al.
Journal of lipid research, 52(12), 2332-2340 (2011-10-01)
Studies have shown a negative association between cellular cholesterol efflux and coronary artery disease (CAD). Standard protocol for quantitating cholesterol efflux involves labeling cells with [(3)H]cholesterol and measuring release of the labeled sterol. Using [(3)H]cholesterol is not ideal for the
James E Shaw et al.
Journal of structural biology, 155(3), 458-469 (2006-08-08)
Elucidating the role that charged membrane proteins play in determining cell membrane structure and dynamics is an area of active study. We have applied in situ correlated atomic force and confocal microscopies to characterize the interaction of the NAP-22 peptide
Frederik W Lund et al.
BMC biophysics, 5, 20-20 (2012-10-20)
Cholesterol is an important membrane component, but our knowledge about its transport in cells is sparse. Previous imaging studies using dehydroergosterol (DHE), an intrinsically fluorescent sterol from yeast, have established that vesicular and non-vesicular transport modes contribute to sterol trafficking
Robert M Littleton et al.
BMC complementary and alternative medicine, 12, 105-105 (2012-07-25)
Consumers are increasingly turning to plant-based complementary and alternative medicines to treat hypercholesterolemia. Many of these treatments are untested and their efficacy is unknown. This multitude of potential remedies necessitates a model system amenable to testing large numbers of organisms
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