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Merck
CN

W381918

L-精氨酸

99%, FCC, FG

别名:

(S)-2-氨基-5-胍基戊酸

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关于此项目

线性分子式:
H2NC(=NH)NH(CH2)3CH(NH2)CO2H
化学文摘社编号:
分子量:
174.20
FEMA Number:
3819
UNSPSC Code:
12164502
eCl@ss:
32160406
PubChem Substance ID:
Flavis number:
17.003
EC Number:
200-811-1
NACRES:
NA.21
MDL number:
Beilstein/REAXYS Number:
1725413
Organoleptic:
faint
Grade:
FG
Biological source:
synthetic
Agency:
meets purity specifications of JECFA
Food allergen:
no known allergens
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产品名称

L-精氨酸, 99%, FCC, FG

assay

99%

SMILES string

N[C@@H](CCCNC(N)=N)C(O)=O

InChI key

ODKSFYDXXFIFQN-BYPYZUCNSA-N

InChI

1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1

biological source

synthetic

grade

FG

agency

meets purity specifications of JECFA

reg. compliance

EU Regulation 1334/2008 & 872/2012
FCC
FDA 21 CFR 172.320

form

powder or crystals

optical activity

[α]20/D +27°, c = 8 in 6 M HCl

mp

222 °C (dec.) (lit.)

application(s)

flavors and fragrances

documentation

see Safety & Documentation for available documents

food allergen

no known allergens

organoleptic

faint

Quality Level

Gene Information

human ... NOS1(4842), NOS2(4843)
rat ... Ppm1a(24666)

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Application


  • 代谢组学方法剖析糖尿病前期发展为2型糖尿病过程中代谢失调:这项研究使用L-精氨酸检查从糖尿病前期过渡到2型糖尿病的代谢变化,为早期干预提供了新的靶点(Ji等人,2024年6月)。文章链接

  • 年龄相关性心房颤动中氨基酸谱的变化:研究了L-精氨酸在心血管衰老中的作用,突出了其在制定针对与衰老相关的心房颤动治疗策略中的潜力(Huang等人,2024年3月)。文章链接

Biochem/physiol Actions

一氧化氮合成酶的底物,可转化为瓜氨酸和一氧化氮 (NO)。通过与一氧化氮相关的机理诱导胰岛素释放。

General description

L -精氨酸是一种氨基酸,在组织修复和生殖等许多生理过程中起关键作用。是哺乳动物体内合成一氧化氮的关键前体。由于这些因素,膳食中补充 L -精氨酸可能会显示出一系列的健康益处。

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Blood pressure and metabolic changes during dietary L-arginine supplementation in humans.
Siani A, et al.
American Journal of Hypertension, 13(5), 547-551 (2000)
L-Arginine Research Progress (2012)
Krishnan Suresh Kumar et al.
European journal of medicinal chemistry, 45(11), 5474-5479 (2010-08-21)
A new series of 3-(benzylideneamino)-2-phenylquinazoline-4(3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4(3)H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex
Diane N Singhroy et al.
Retrovirology, 10, 73-73 (2013-07-23)
Protein arginine methyltransferase 6 (PRMT6) is a nuclear enzyme that methylates arginine residues on histones and transcription factors. In addition, PRMT6 inhibits HIV-1 replication in cell culture by directly methylating and interfering with the functions of several HIV-1 proteins, i.e.
Palaniraja Thandapani et al.
Molecular cell, 50(5), 613-623 (2013-06-12)
Motifs rich in arginines and glycines were recognized several decades ago to play functional roles and were termed glycine-arginine-rich (GAR) domains and/or RGG boxes. We review here the evolving functions of the RGG box along with several sequence variations that

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