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质量水平
方案
≥90%
表单
powder
储存温度
−20°C
SMILES字符串
OC(=O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1
InChI
1S/C14H9I3O4/c15-9-6-8(1-2-12(9)18)21-14-10(16)3-7(4-11(14)17)5-13(19)20/h1-4,6,18H,5H2,(H,19,20)
InChI key
UOWZUVNAGUAEQC-UHFFFAOYSA-N
基因信息
human ... THRA(7067) , THRB(7068)
rat ... Thra(81812) , Thrb(24831)
应用
- 甲状腺激素研究：研究3,3′,5-三碘甲腺乙酸对MCT8缺陷患者的外周和神经发育影响，说明它的甲状腺相关发育疾病的治疗潜力(Unsal and Hayran, 2024)。
- 神经疾病治疗：研究用3,3′,5-三碘甲腺乙酸解决Allan-Herndon-Dudley综合征模拟大脑类器官的T3摄入和作用异常，为治疗大脑特异性甲状腺激素转运异常提供依据(Salas-Lucia et al., 2024)。
- 抗病毒治疗的药物发展：Tiratricol是3,3′,5-三碘甲腺乙酸的衍生物，研究发现它可通过靶向依赖病毒RNA的RNA聚合酶抑制黄热病毒复制，显示抗病毒药物开发潜力(Ren et al., 2023)。
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Leandro Martínez et al.
Journal of medicinal chemistry, 49(1), 23-26 (2006-01-06)
Steered molecular dynamics simulations of ligand dissociation from Thyroid hormone receptors indicate that dissociation is favored via rearrangements in a mobile part of the LBD comprising H3, the loop between H1 and H2, and nearby beta-sheets, contrary to current models
Debora Lucia Seguro Danilovic et al.
Thyroid : official journal of the American Thyroid Association, 18(6), 655-657 (2008-06-27)
Mesotherapy consists of cutaneous injections of a mixture of compounds and has recently been used for cosmetic purposes to reduce local fat and cellulite. To date, several reports have described only local adverse events related to this therapy. We describe
Warren J L Wood et al.
Chembiochem : a European journal of chemical biology, 10(2), 361-365 (2008-12-24)
3-Iodothyronamine (T(1)AM) and 3,3',5-triiodothyroacetic acid (Triac) are bioactive metabolites of the hormone thyroxine (T(4)). In the present study, the ability of T(1)AM and 3,3',5-triiodothyronamine (T(3)AM) to be metabolized to 3-iodothyroacetic acid (TA(1)) and Triac, respectively, was investigated. Both T(1)AM and
Wim Klootwijk et al.
Endocrinology, 152(8), 3259-3267 (2011-06-10)
Thyroid hormone (TH) is important for metamorphosis in many species, including the cephalochordate Branchiostoma floridae, a marine invertebrate (amphioxus) living in warmer coastal areas. Branchiostoma expresses a TH receptor, which is activated by 3,3',5-triiodothyroacetic acid (TA(3)) but not by T(3).
Mathilde Paris et al.
Integrative and comparative biology, 50(1), 63-74 (2011-05-12)
Thyroid hormones (THs), and more precisely the 3,3',5-triiodo-l-thyronine (T(3)) acetic derivative 3,3',5-triiodothyroacetic acid (TRIAC), have been shown to activate metamorphosis in amphioxus. However, it remains unknown whether TRIAC is endogenously synthesized in amphioxus and more generally whether an active TH
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