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安全信息

927066

Sigma-Aldrich

TissueFab® bioink kit

Fibronectin-UV/365nm

别名:

3D Bioprinting, Bioink, Fibronectin, GelMA, GelMA-UV fibronectin kit, Gelatin methacrylamide, Gelatin methacrylate, Gelatin methacryloyl, Low endotoxin, Suitable for 3D bioprinting applications, TissueFab

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20 μG
CN¥3,096.05
50 μG
CN¥5,521.21

CN¥3,096.05

预计发货时间July 21, 2025详情

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20 μG
CN¥3,096.05
50 μG
CN¥5,521.21

About This Item

UNSPSC代码:
12352201
NACRES:
NA.25

CN¥3,096.05

预计发货时间July 21, 2025详情

获取大包装报价

质量水平

100

表单

viscous liquid (gel)

杂质

<5 CFU/g Bioberden: Aerobic
<5 CFU/g Bioberden: Fungal
<50 EU/mL Endotoxin

颜色

pale yellow to colorless

pH值（酸碱度）

6.5-7.5

粘度

3-30 cP

应用

3D bioprinting

储存温度

2-8°C

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EHU025551EHU010991EHU040421
MISSION&#174; esiRNA targeting human SLC9A3

EHU149191

MISSION® esiRNA

MISSION&#174; esiRNA targeting human SLC9A1

EHU025551

MISSION® esiRNA

MISSION&#174; esiRNA targeting human SLC1A3

EHU010991

MISSION® esiRNA

MISSION&#174; esiRNA targeting human SLC9A7 (2)

EHU040421

MISSION® esiRNA

esiRNA cDNA target sequence

GACCAGGTGGTCCTGTCCTACGGGGGCCTGCGCGGGGCCGTGGCCTTTGCCCTGGTGGTGCTTCTGGATGGAGACAAGGTCAAGGAGAAGAACCTGTTCGTCAGCACCACCATCATCGTAGTGTTCTTCACCGTCATCTTCCAGGGCCTGACCATCAAGCCTCTGGTGCAGTGGCTGAAGGTGAAGAGGAGCGAGCACCGGGAACCTCGGCTCAACGAGAAGCTGCACGGGCGCGCTTTCGACCACATCCTCTCGGCCATCGAGGACATATCCGGACAGATCGGGCACAATTATCTCAGAGACAAGTGGTCCCACTTCGACAGGAAGTTCCTCAGCAGGGTCCTCATGAGACGGTCGGCCCAGAAGTCTCGAGACCGGATCCTGAATGTCTTCCACGAGCTG

esiRNA cDNA target sequence

CACCACTGGAACTGGACCTTCGTCATCAGCACCCTGCTCTTCTGCCTCATCGCCCGCGTGCTGGGGGTGCTGGGCCTGACCTGGTTCATCAACAAGTTCCGTATCGTGAAGCTGACCCCCAAGGACCAGTTCATCATCGCCTATGGGGGCCTGCGAGGGGCCATCGCCTTCTCTCTGGGCTACCTCCTGGACAAGAAGCACTTCCCCATGTGTGACCTGTTCCTCACTGCCATCATCACTGTCATCTTCTTCACCGTCTTTGTGCAGGGCATGACCATTCGGCCCCTGGTAGACCTGTTGGCTGTGAAGAAAAAGCAAGAGACGAAGCGCTCCATCAACGAAGAGATCCACACACAGTTCCTGGACCACCTTCTGACAGGCATCGAAGACATCTGTGGCCACTACGGTCACCACCACTG

esiRNA cDNA target sequence

TTCTCCTTTCCTGGGGAACTTCTGATGAGGATGTTACAGATGCTGGTCTTACCACTTATCATCTCCAGTCTTGTCACAGGAATGGCGGCGCTAGATAGTAAGGCATCAGGGAAGATGGGAATGCGAGCTGTAGTCTATTATATGACTACCACCATCATTGCTGTGGTGATTGGCATAATCATTGTCATCATCATCCATCCTGGGAAGGGCACAAAGGAAAACATGCACAGAGAAGGCAAAATTGTACGAGTGACAGCTGCAGATGCCTTCCTGGACTTGATCAGGAACATGTTCCCTCCAAATCTGGTAGAAGCCTGCTTTAAACAGTTTAAAACCAACTATGAGAAGAGAAGCTTTAAAGTGCCCATCCAGGCCAACGAAACGCTTGTGGGTGCTGTGATAAACAATGTGTCTGAGGCCATGGAGACTCT

esiRNA cDNA target sequence

TGGCAAGATCAACAGCGTAGAGCAGAATGATATGCTACGGAAGGTAACATTCGATCCAGAAGTATTTTTCAACATTCTTCTGCCTCCAATTATTTTTCATGCTGGATACAGCTTAAAGAAGAGACACTTTTTCAGAAATCTTGGATCTATACTGGCCTATGCCTTCTTGGGGACTGCTGTTTCATGCTTCATTATTGGAAATCTCATGTATGGTGTGGTGAAGCTCATGAAGATTATGGGACAGCTCTCAGATAAATTTTACTACACAGATTGTCTCTTTTTTGGAGCAATCATCTCTGCCACTGACCCAGTGACTGTGCTGGCGATATTTAATGAATTGCATGCAGACGTGGATCTTTACGCACTTCTTTTTGGAGAGAGCGTCCTAAATGATGCTGTTGCCATTGTACTGTCCTCGTCTATTGTTGCCTACCAGCCAGCGGGACTGAACACTCACGCCTTTGA

product line

MISSION®

product line

MISSION®

product line

MISSION®

product line

MISSION®

Gene Information

human ... SLC9A3(6550), SLC9A3(6550)

Gene Information

human ... SLC9A1(6548), SLC9A1(6548)

Gene Information

human ... SLC1A3(6507), SLC1A3(6507)

Gene Information

human ... SLC9A7(84679), SLC9A7(84679)

Ensembl | human accession no.

ENSG00000066230

Ensembl | human accession no.

ENSG00000090020

Ensembl | human accession no.

ENSG00000079215

Ensembl | human accession no.

ENSG00000065923

NCBI accession no.

NM_004174

NCBI accession no.

NM_003047

NCBI accession no.

NM_004172

NCBI accession no.

NM_032591

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

一般描述

Gelatin methacryloyl (GelMA) is a polymerizable hydrogel material derived from natural extracellular matrix (ECM) components. Due to its low cost, abundance, and retention of natural cell binding motifs, gelatin has become a highly sought material for tissue engineering applications. Laminin is an extracellular matrix multidomain trimeric glycoprotein and is the main non-collagenous component of basal lamina that supports adhesion, proliferation and differentiation. Fibronectin is a multifunctional glycoprotein which exists as two major isoforms, one soluble and one insoluble form. The former is present in plasma, whereas the insoluble form resides in tissues and extracellular matrix (ECM) of cartilage. Fibronectin is known to contain integrin binding sequences which facilitate cell-matrix interactions. Fibronectin plays an essential role in multiple biological functions such as, angiogenesis, cell migration and differentiation and wound healing.

应用

The addition of photocrosslinkable methacrylamide functional groups in GelMA allows the synthesis of biocompatible, biodegradable, and non-immunogenic hydrogels that are stable in biologically relevant conditions and promote cell adhesion, spreading, and proliferation Gelatin methacrylate based bioinks have been used to bioprint osteogenic [1], chondrogenic [2][3], hepatic [4][5][6], adipogenic [7], vasculogenic [8], epithelial [6], endothelial [9][10], cardiac valve [11], skin [12], tumor [10] and other tissues and constructs. Fibronectin has been used in tissue engineering applications for wound healing and angiogenesis [13], bone repair [14] and studying mechanotransduction.
TissueFab® - GelMA Fibronectin bioink kit UV/365 features a ready-to-use bioink that is formulated for high cell viability, and printability and is designed for extrusion-based 3D bioprinting and subsequent 365 nm light crosslinking and a solution of Fibronectin to enhance the bioink. The bioink kit can be used with most extrusion-based bioprinters, are biodegradable, and are compatible with human dermal fibroblasts (HDFs) and other diverse cell types. TissueFab® - GelMA Fibronectin bioink kit UV/365 enables the precise fabrication of 3D cell models and tissue constructs for research in 3D cell biology, tissue engineering, in vitro tissue models, and regenerative medicine. Suitable for final Fibronectin concentrations up to 200 μg/ml.

特点和优势

In addition to fast gelation, the methacrylamide functional group can also be used to control the hydrogel physical parameters such as pore size, degradation rate, and swell ratio. Temporal and spatial control of the crosslinking reaction can be obtained by adjusting the degree of functionalization and polymerization conditions, allowing for the fabrication of hydrogels with unique patterns, 3D structures, and morphologies.Low Endotoxin, low bioburden: Endotoxins have been demonstrated negatively impact cellular growth, morphology, differentiation, inflammation and protein expression. Bioburden is defined as the number of contaminated organisms found in a given amount of material. We test each lot for endotoxins as well as total bioburden (aerobic and fungal) to minimize unwanted interactions. For more information: https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/microbiological-testing/pyrogen-testing/what-is-endotoxin

法律信息

TISSUEFAB is a registered trademark of Merck KGaA, Darmstadt, Germany

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    Stephanie K Seidlits et al.
    Acta biomaterialia, 7(6), 2401-2409 (2011-03-29)
    Biomaterials that actively promote both wound healing and angiogenesis are of critical importance for many biomedical applications, including tissue engineering. In particular, hyaluronic acid (HA) is an important player that has multiple roles throughout the angiogenic process in the body.
    Marta Kisiel et al.
    Biomaterials, 34(3), 704-712 (2012-10-30)
    While human bone morphogenetic protein-2 (rhBMP-2) is a promising growth factor for bone regeneration, its clinical efficacy has recently shown to be below expectation. In order to improve the clinical translation of rhBMP-2, there exists strong motivation to engineer better
    Alice E Stanton et al.
    Acta biomaterialia, 96, 310-320 (2019-07-01)
    Extracellular matrix (ECM) is comprised of different types of proteins, which change in composition and ratios during morphogenesis and disease progression. ECM proteins provide cell adhesion and impart mechanical cues to the cells. Increasing substrate stiffness has been shown to
    Wanjun Liu et al.
    Advanced healthcare materials, 6(12) (2017-05-04)
    Bioprinting is an emerging technique for the fabrication of 3D cell-laden constructs. However, the progress for generating a 3D complex physiological microenvironment has been hampered by a lack of advanced cell-responsive bioinks that enable bioprinting with high structural fidelity, particularly
    Birgit Huber et al.
    Journal of biomaterials applications, 30(6), 699-710 (2015-05-29)
    In vitro engineering of autologous fatty tissue constructs is still a major challenge for the treatment of congenital deformities, tumor resections or high-graded burns. In this study, we evaluated the suitability of photo-crosslinkable methacrylated gelatin (GM) and mature adipocytes as components
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