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Dear Customer:

The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

Merck
CN
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主要文件

568600

Sigma-Aldrich

6-(马来酰亚胺基)己酸琥珀酰亚胺酯

98%

别名:

6-马来酰亚氨基己酸 N-琥珀酰亚胺酯, N-(ε-马来酰亚胺己酰氧)琥珀酰亚胺, N-琥珀酰亚胺 6-马来酰亚胺己酸酯, EMCS

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50 G
CN¥2,731.81

CN¥2,731.81


预计发货时间June 30, 2025详情


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50 G
CN¥2,731.81

About This Item

经验公式(希尔记法):
C14H16N2O6
CAS号:
分子量:
308.29
Beilstein:
1499815
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

CN¥2,731.81


预计发货时间June 30, 2025详情


获取大包装报价

质量水平

方案

98%

反应适用性

reagent type: cross-linking reagent

mp

70-73 °C (lit.)

官能团

NHS ester
imide
maleimide

储存温度

−20°C

SMILES字符串

O=C(ON(C(CC1)=O)C1=O)CCCCCN2C(C=CC2=O)=O

InChI

1S/C14H16N2O6/c17-10-5-6-11(18)15(10)9-3-1-2-4-14(21)22-16-12(19)7-8-13(16)20/h5-6H,1-4,7-9H2

InChI key

VLARLSIGSPVYHX-UHFFFAOYSA-N

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6317763179M9794
assay

98%

assay

≥98.0% (HPLC)

assay

≥98.5% (HPLC)

assay

≥98%

reaction suitability

reagent type: cross-linking reagent

reaction suitability

reagent type: linker

reaction suitability

reagent type: linker

reaction suitability

reagent type: linker

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

mp

70-73 °C (lit.)

mp

67-73 °C, 70-73 °C (lit.)

mp

167-171 °C

mp

70-73 °C (lit.)

functional group

NHS ester

functional group

NHS ester

functional group

NHS ester

functional group

NHS ester

应用

6-马来酰亚胺己酸N-羟基琥珀酰亚胺酯可用于:
  • 通过马来酰亚胺硫醇连接反应合成马来酰亚胺活化碳水化合物,用于含半胱氨酸的多肽和蛋白质的位点特异性糖基化。[1]
  • 含有马来酰亚胺侧链作为抗肿瘤剂的阿霉素葡糖苷酸前药的合成。[2]
  • 将寡核苷酸与底物上的氨基交联以制备DNA微阵列。[3]

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

  • 技术规格说明书

  • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number

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    Synthesis and antitumor efficacy of a β-glucuronidase-responsive albumin-binding prodrug of doxorubicin.
    Legigan T, et al.
    Journal of Medicinal Chemistry, 55(9), 4516-4520 (2012)
    Microarray fabrication with covalent attachment of DNA using bubble jet technology.
    Okamoto T, et al.
    Nature Biotechnology, 18(4), 438-438 (2000)
    Synthesis of maleimide-activated carbohydrates as chemoselective tags for site-specific glycosylation of peptides and proteins.
    Ni J, et al.
    Bioconjugate Chemistry, 14(1), 232-238 (2003)
    N J Maeji et al.
    Journal of immunological methods, 146(1), 83-90 (1992-01-21)
    Recently, the multipin approach for simultaneous multiple peptide synthesis was applied to the analysis of T cell determinants by using a novel cleavage method (Maeji et al., 1990). A diketopiperazine forming linker allowed cleavage of peptides into aqueous buffer which
    Y Nakano et al.
    International archives of allergy and immunology, 120(3), 199-208 (1999-12-11)
    We have previously reported that ovalbumin (OVA) coupled with liposome via glutaraldehyde (GA) induced OVA-specific- and IgE-selective unresponsiveness in mice. In this study, OVA-liposome conjugates were made using four different coupling protocols: via GA, N-(6-maleimidocaproyloxy) succinimide (EMCS), disuccinimidyl suberate (DSS)

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