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描述
amino surface groups
质量水平
形式
liquid
分子量
generation 5.0
特点
core type ethylenediamine core (2-carbon core)
浓度
5 wt. % in methanol
表面基团编号
128
密度
0.797 g/mL at 25 °C
储存温度
2-8°C
一般描述
PAMAM 树状大分子是水溶性、非免疫原性和生物相容性的对称聚合物。它具有大量可修饰的末端官能团，可以与各种靶分子或客体分子结合。这些末端基团用于共价连接药物、靶向配体或显像剂，用于靶向递送、控制释放或成像应用。
应用
- Synthesis of beta-Cyclodextrin-Decorated Dendritic Compounds Based on EDTA Core: This study presents an alternative to the ethylenediamine core in PAMAM dendrimers, using an EDTA core instead, providing insights into modifications that affect the dendrimers properties (Gonzalez Mendez et al., 2022).
- New Advances in General Biomedical Applications of PAMAM Dendrimers: Discusses the composition variations of PAMAM dendrimer cores, including ethylenediamine, and their implications on biomedical applications (Araujo et al., 2018).
- Poly (amidoamine) Dendrimers: Covalent and Supramolecular Synthesis: This paper reviews various synthetic strategies for PAMAM dendrimers, emphasizing the role of the ethylenediamine core in their structural formation (Lyu et al., 2019).
- Modified Carboxyl-Terminated PAMAM Dendrimers as a Cytocompatible Nano Based Drug Delivery System: Examines the biocompatibility and drug delivery efficiency of modified PAMAM dendrimers, highlighting the cores critical role (Vu et al., 2019).
- Use of Polyaminoamide Dendrimers Starting from Different Core-Initial Molecules for Inhibition of Silica Scale: This study explores the use of ethylenediamine-core PAMAM dendrimers in industrial applications, particularly for silica scale inhibition (Sun et al., 2021).
外形
含有 128 个表面伯氨基。
法律信息
由Dendritech®公司制造。
Dendritech is a registered trademark of Dendritech, Inc.
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes
WGK
WGK 3
闪点(°F)
49.5 °F
闪点(°C)
9.7 °C
法规信息
新产品
Catriona H Edwards et al.
Scientific reports, 10(1), 12422-12422 (2020-07-28)
In this study, the use of dendrimer-coated carbon nanotubes (CNTs) as a delivery vehicle for dsRNA was assessed in Tribolium castaneum. Exposure to low dosages of polyamidoamine dendrimer carbon nanotubes (PAMAM-CNTs) did not affect T. castaneum larval mortality. Expression of
The effect of PAMAM dendrimer generation size and surface functional group on the aqueous solubility of nifedipine
Bharathi Devarakonda, et al.
International Journal of Pharmaceutics, 284, 133-140 (2004)
Roberta Risoluti et al.
Journal of pharmaceutical analysis, 10(4), 351-355 (2020-09-15)
In this work, functionalized carbon nanotubes (CNTs) using two polyamine polymers, polyethyleneimine (PEI) and polyamidoamine dendrimer (PAMAM), were investigated by thermal analysis in order to address preparation strategies to obtain low cytotoxic compounds with the ability to conjugate microRNAs and
Zhao-Jun Liu et al.
PloS one, 11(4), e0154053-e0154053 (2016-04-23)
Stem cell therapy has emerged as a promising approach for treatment of a number of diseases, including delayed and non-healing wounds. However, targeted systemic delivery of therapeutic cells to the dysfunctional tissues remains one formidable challenge. Herein, we present a
Drug release characteristics of PAMAM dendrimer?drug conjugates with different linkers
Yunus E. Kurtoglu, et al.
International Journal of Pharmaceutics, 384, 189-194 (2010)
商品
Replace volatile organic solvents with water due to environmental concerns, overcoming challenges in solubility.
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