所有图片(2)
About This Item
线性分子式:
HCOCH2NHCO2C(CH3)3
CAS号:
分子量:
159.18
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
推荐产品
质量水平
方案
95%
折射率
n20/D 1.455 (lit.)
官能团
aldehyde
amine
储存温度
−20°C
SMILES字符串
CC(C)(C)OC(=O)NCC=O
InChI
1S/C7H13NO3/c1-7(2,3)11-6(10)8-4-5-9/h5H,4H2,1-3H3,(H,8,10)
InChI key
ACNRTYKOPZDRCO-UHFFFAOYSA-N
基因信息
human ... CTSK(1513)
相关类别
一般描述
N -Boc-2-氨基乙醛是一种有机构件。与 Horner-Wadsworth-Emmons (HWE) 试剂反应，得到 γ-氨基丁酸 (GABA) 衍生的 α-酮酰胺/酯单元。
应用
N -Boc-2-氨基乙醛可用于以下用途：
- 作为 (+)-负霉素全合成中的起始试剂。
- ( E )-4-（（ 叔 -丁氧基羰基）氨基）-2-烯酸乙酯的合成。
- 2,2′ 的合成-联吡啶。
使用最近报道的涉及甲醛和吡咯烷丙酸或二肽 L-Pro-β-Ala 催化的方案，该氨基醛的 α-亚甲基化以快速有效的方式进行。
也用于含 1,3-偶极环加成的吡咯烷的三组分合成。
也用于含 1,3-偶极环加成的吡咯烷的三组分合成。
受保护的吡咯脯氨酸合成中的一个组成部分。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
235.4 °F - closed cup
闪点(°C)
113 °C - closed cup
个人防护装备
Eyeshields, Gloves, type N95 (US)
Anna Turetsky et al.
Scientific reports, 4, 4782-4782 (2014-04-25)
A number of Bruton's tyrosine kinase (BTK) inhibitors are currently in development, yet it has been difficult to visualize BTK expression and pharmacological inhibition in vivo in real time. We synthesized a fluorescent, irreversible BTK binder based on the drug
Diethyl [3-Cyano-2-Oxo-3-(Triphenylphosphoranylidene) propyl] phosphonate: A Useful Horner-Wadsworth-Emmons Reagent for alpha-Keto (Cyanomethylene)-triphenylphosphoranes from Carbonyl Compounds.
Lee K.
Bull. Korean Chem. Soc., 28(10), 1641-1641 (2007)
Anniina Erkkilä et al.
The Journal of organic chemistry, 71(6), 2538-2541 (2006-03-11)
A rapid and extremely convenient method for alpha-methylenation of aldehydes with aqueous formaldehyde is described. Two optimal catalytic systems are presented that allow short reaction times and afford the functionalized products in good to excellent yields (up to 99%) and
Efficient total synthesis of (+)-negamycin, a potential chemotherapeutic agent for genetic diseases.
Yoshio Hayashi et al.
Chemical communications (Cambridge, England), (20)(20), 2379-2381 (2008-05-14)
Herein, we describe an efficient strategy for the total synthesis of (+)-negamycin using commercially available achiral N-Boc-2-aminoacetaldehyde as starting material with 42% overall yield for a limited number of steps.
The Journal of Organic Chemistry, 70, 10869-10869 (2005)
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