跳转至内容
Merck
CN
所有图片(2)

文件

安全信息

430471

Sigma-Aldrich

聚（D,L-丙交酯-co-乙交酯）

ester terminated, Mw 50,000-75,000

登录查看公司和协议定价
所有图片(2)
别名:
Lactel® B6006-1, PLGA
线性分子式:
[C3H4O2]x[C2H2O2]y
MDL编号:
MFCD00131930
UNSPSC代码:
12162002
PubChem化学物质编号:
24866924
NACRES:
NA.23

质量水平

100

形式

amorphous

投料比

lactide:glycolide 85:15

分子量

Mw 50,000-75,000

降解时间线

<6 months

粘度

0.55-0.75 dL/g, 0.1 % (w/v) in chloroform(25 °C)

转变温度

Tg 45-50 °C

溶解性

ethyl acetate, chloroform, acetone and THF: soluble

储存温度

2-8°C

SMILES字符串

OCC(O)=O.CC(O)C(O)=O

正在寻找类似产品? 访问 产品对比指南

相关类别

一般描述

封端酯基聚（D,L-丙交酯-乙交酯）(PLGA) 的特征特性为 体内 生物降解性、可调谐药物释放特性和极高的包封能力。

应用

PLGA 聚合物用于生产生物可降解医用缝线和控制药物释放。PLGA 微球已被报道用于人生长激素的控制释放。PLGA/聚己内酯/β 组成的共混聚合物薄膜-磷酸三钙已用于引导骨再生。

特点和优势

控释生物活性剂、缝线和可生物吸收植入器件。

外形

具有生物相容性且可生物降解的聚合物。

法律信息

Lactel is a registered trademark of Evonik Corp

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What are the end groups of Product No. 430471 (Poly(DL-lactide-co-glycolide)?

    Product 430471 has a dodecyl (12 carbon) ester on one end of the polymer chain and a hydroxyl end group on the other.

  6. What is the density of Product No. 430471 Poly(DL-lactide-co-glycolide)?

    According to the manufacturer, product 430471 has a theoretical density of 1.27g/mL.

  7. How is this Product No. 430471 synthesized (Poly(DL-lactide-co-glycolide)?

    To synthesize product 430471, 1-dodecanol is used as an initiator and stannous octoate is used as a catalyst to start the ring opening polymerization of D,L-lactide and glycolide monomers.

  8. What is the tensile strength of Product No. 403471 Poly(DL-lactide-co-glycolide)?

    Product 430471 has a tensile strength of 6000 - 8000 psi, with an elongation of 3-10%.

  9. Is Product No. 403471 a resorbable polymer?

    Yes, Product No. 430471 has a resorption time of 5-6 months.

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Preparation and characterization of poly (D, L-lactide-co-glycolide) microspheres for controlled release of human growth hormone
Capan Y, et al.
Aaps Pharmscitech, 4(2), 147-156 (2003)
Fabrication of blended polycaprolactone/poly (lactic-co-glycolic acid)/?-tricalcium phosphate thin membrane using solid freeform fabrication technology for guided bone regeneration
Shim JH, et al.
Tissue Engineering: Part A, 19(3-4), 317-328 null
Manjae Gil et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 5(6), 1800024-1800024 (2018-06-26)
Anisotropically compartmentalized microparticles have attracted increasing interest in areas ranging from sensing, drug delivery, and catalysis to microactuators. Herein, a facile method is reported for the preparation of helically decorated microbuilding blocks, using a modified electrohydrodynamic cojetting method. Bicompartmental microfibers
Ayelen L Helling et al.
Tissue engineering. Part A, 25(3-4), 214-223 (2018-10-04)
In human skin the junction between the epidermis and dermis undulates. Epidermal stem cells pattern according to their position relative to those undulations. Here we describe a rig in which epidermal cells are cultured on a collagen-coated poly(d,l-lactide-co-glycolide) (PLGA) membrane.
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
查看所有相关文献

商品

RESOMER® - Biodegradable Polymers for Sutures, Medical Devices, Drug Delivery Systems and Tissue Engineering

Interest in utilizing biodegradable polymers for biomedical applications has grown since the 1960s.

聚甘油癸二酸酯在组织工程和再生医学的应用

商业生物材料已停滞不前超过30年的时间，因为很少有材料能够成功地从实验台过渡到临床使用。合成型脂族聚酯因其悠久的历史和获得美国食品药品监督管理局（FDA）批准的记录，一直在可吸收生物材料领域占据主导地位。

Poly(Glycerol Sebacate) in Tissue Engineering

Synthetic aliphatic polyesters dominate resorbable biomaterials in clinical use.

Biodegradable Polyester Nanoparticle Formation

AliAliphatic polyesters, including polylactide and polyglycolide, are biodegradable polymers widely used in medical applications.

查看所有结果

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门