所有图片(1)
About This Item
经验公式（希尔记法）:
C6H7N5O
CAS号:
分子量:
165.15
Beilstein:
645384
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
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方案
97%
mp
>300 °C (lit.)
SMILES字符串
COc1nc(N)nc2[nH]cnc12
InChI
1S/C6H7N5O/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11)
InChI key
BXJHWYVXLGLDMZ-UHFFFAOYSA-N
基因信息
human ... CDK2(1017) , MGMT(4255)
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一般描述
6-O-甲基鸟嘌呤是一种嘌呤衍生物，它的结合亲和力已通过使用等温滴定热法（ITC）利用枯草芽孢杆菌xpt-pbuX鸟嘌呤核糖开关（GR）进行了检查。6-O-甲基鸟嘌呤是在一系列纯化的tRNA制剂的烷基化过程中通过与致癌物N-甲基-N-亚硝基脲反应而形成的。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Delia Chavarria et al.
Journal of molecular biology, 412(3), 325-339 (2011-08-09)
O(6)-methylguanine (O(6)-MeG) is a miscoding DNA lesion arising from the alkylation of guanine. This report uses the bacteriophage T4 DNA polymerase as a model to probe the roles of hydrogen-bonding interactions, shape/size, and nucleobase desolvation during the replication of this
Chiung-Wen Hu et al.
Analytical and bioanalytical chemistry, 402(3), 1199-1208 (2011-11-19)
Since methylation at the N-7 and O(6) positions of guanine and the N-3 position of adenine in DNA are the predominant reaction sites, N(7)-methylguanine (N(7)-MeG), O(6)-methylguanine (O(6)-MeG), and N(3)-methyladenine (N(3)-MeA) have been suggested as good biomarkers for assessing exposure to
Alkylation of transfer RNA by N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea.
A E Pegg
Chemico-biological interactions, 6(6), 393-406 (1973-06-01)
V V Lylo et al.
TSitologiia i genetika, 45(6), 53-60 (2012-02-15)
The aim of our study was to investigate the effect of recombinant human cytokine EMAP II (endothelial monocyte-activating polypeptide II) on the expression of MGMT gene, encoding repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) in human cell cultures. The influence of EMAP
Sharon E Murphy et al.
Cancer prevention research (Philadelphia, Pa.), 4(11), 1752-1760 (2011-10-27)
Nicotine replacement therapy is often used to maintain smoking cessation. However, concerns exist about the safety of long-term nicotine replacement therapy use in ex-smokers and its concurrent use in smokers. In this study, we determined the effect of nicotine administration
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