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123080

Sigma-Aldrich

2-氨基-4-甲基吡啶

99%

别名:

2-氨基-4-甲基吡啶

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About This Item

经验公式（希尔记法）:
C6H8N2
CAS号:
695-34-1
分子量:
108.14
Beilstein:
107066
EC 号:
211-780-9
MDL编号:
MFCD00006321
UNSPSC代码:
12352100
PubChem化学物质编号:
24847520
NACRES:
NA.22

质量水平

100

方案

99%

沸点

230 °C (lit.)

mp

96-99 °C (lit.)

溶解性

DMF: freely soluble
H2O: freely soluble
aliphatic hydrocarbons: slightly soluble
coal tar bases: freely soluble
lower alcohols: freely soluble
petroleum ether: slightly soluble

SMILES字符串

Cc1ccnc(N)c1

InChI

1S/C6H8N2/c1-5-2-3-8-6(7)4-5/h2-4H,1H3,(H2,7,8)

InChI key

ORLGLBZRQYOWNA-UHFFFAOYSA-N

基因信息

human ... NOS1(4842) , NOS2(4843) , NOS3(4846)
rat ... Nos1(24598)

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相关类别

一般描述

2-氨基-4-甲基吡啶作为配体，形成甲氧基桥联的铜 (II) 配合物 。

应用

2-氨基-4-甲基吡啶用于合成 2-氨基-4-甲基吡啶-2-羟基苯甲酸盐 。

生化/生理作用

2-氨基-4-甲基吡啶抑制体外 小鼠 RAW 264.7 细胞分离的诱导型 NO 合成酶的活性 。

象形图

Skull and crossbonesCorrosion
GHS06,GHS05

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1B

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 2

闪点(°F)

244.4 °F - closed cup

闪点(°C)

118 °C - closed cup

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCW2715
MKCT7902
MKCS5060
MKCP8780
MKCP2289

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W S Faraci et al.
British journal of pharmacology, 119(6), 1101-1108 (1996-11-01)
1. The ability of 2-amino-4-methylpyridine to inhibit the catalytic activity of the inducible NO synthase (NOS II) enzyme was characterized in vitro and in vivo. 2. In vitro, 2-amino-4-methylpyridine inhibited NOS II activity derived from mouse RAW 264.7 cells with
Sherif Y Saad et al.
Chemotherapy, 48(6), 309-315 (2003-04-04)
Nitric oxide (NO) has been shown to play a role in maintaining normal renal function. However, the role of NO in cisplatin (CDDP)-induced nephrotoxicity is still unclear. The aim of the present work was to examine the effect of the
Madhukar Hemamalini et al.
Acta crystallographica. Section E, Structure reports online, 66(Pt 8), o2151-o2152 (2010-01-01)
The asymmetric unit of the title mol-ecular salt, C(6)H(9)N(2) (+)·C(7)H(5)O(3) (-), contains two cations and two anions. Both the salicylate anions contain an intra-molecular O-H⋯O hydrogen bond, which generates an S(6) ring. Both the 2-amino-4-methyl-pyridine mol-ecules are protonated at their
N Kiloh et al.
European journal of pharmacology, 70(1), 53-57 (1981-03-05)
4-Methyl-2-aminopyridine (4M2AP) increased responses of isolated rat diaphragm and chick biventer cervicis nerve-muscle preparations to nerve stimulation but depressed responses to direct stimulation. Responses to acetylcholine were also increased while responses to carbachol were depressed. When tested after inhibition of
R Boer et al.
Molecular pharmacology, 58(5), 1026-1034 (2000-10-20)
We have investigated various nitric oxide (NO) synthase inhibitors for their affinity and selectivity toward the three human isoenzymes in radioligand binding experiments. Therefore, we developed the new radioligand [(3)H]2-amino-4-picoline to measure binding of these compounds to the three human
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