Authenticated Pancreatic Cancer Cell Lines

Read more about

• Types of Pancreatic Cancer
• Risk Factors
• Mutations
• Small Molecules/Monoclonal Antibodies
• Applications
• ECACC Pancreatic Cancer Cell Lines
• References

In developed countries, pancreatic cancer is one of the leading causes of mortality due to cancer. A 2012 GLOBOCAN estimate attributed 331,000 deaths annually to pancreatic cancer. Subclinical symptoms in the early stages of disease often leads to delayed diagnosis and a poor prognosis, with an estimated 5-year survival rate of less than 5%. If outcomes are not improved, pancreatic cancer is projected to become the second leading cause of cancer-related death in next decade.

Types of pancreatic cancer

Pancreatic cancer may originate from either the exocrine or endocrine compartment of the pancreas. The table below delineates differences between exocrine and endocrine tumors, and will aid in the selection of the appropriate cell line for your research.

Risk factors

Age is the major risk factor for pancreatic cancer; patients above 50 years of age are at higher risk. Lifestyle factors include smoking, obesity, low physical activity.  Diabetes mellitus can be both a risk factor and a consequence of early-stage pancreatic cancer.

Mutations

Approximately 10% of pancreatic cancer patients have a family history of cancer; individuals with mutations in KRAS, TP53, GNAS, SMAD4, CDKN2A, RNF43, ARID1A, and KMT2C may be at higher risk.

Choose cell lines from the table below based on mutation, and click genes to find relevant products (antibodies, shRNA, siRNA, primers, CRISPR plasmids) for your research study.

Small molecules/monoclonal antibodies

Small molecule compounds and antibodies can be used to target cancer cells and block tumor growth and progression.  There are small molecule compounds that can target pancreatic cancer based on type of cancer. Drugs used to target pancreatic cancer include:

• Erlotinib
• Capecitabine
• Fluorouracil
• Gemcitabine
• Leucovorin
• Oxaliplatin
• Irinotecan
• Nab-paclitaxel

Applications

Cancer cell lines are indispensable for cancer research, as they provide an accessible, cost-effective model for cellular behavior and response. Based on the characteristics of the cell origins and the experimental need, cell lines may be used in one or more applications. Some examples of application-specific cell line use are included below.