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  • The inhibition of TNF-alpha-induced NF-kappaB activation by marine natural products.

The inhibition of TNF-alpha-induced NF-kappaB activation by marine natural products.

Biochemical pharmacology (2009-05-19)
Florence Folmer, Marcel Jaspars, Godofredo Solano, Silvia Cristofanon, Estelle Henry, Jioji Tabudravu, Kenny Black, David H Green, Frithjof C Küpper, William Aalbersberg, Klaus Feussner, Mario Dicato, Marc Diederich
PMID19445900
ABSTRACT

The deregulated activation of NF-kappaB is associated with cancer development and inflammatory diseases. With an aim to find new NF-kappaB inhibitors, we purified and characterized compounds from extracts of the Fijian sponge Rhabdastrella globostellata, the crinoid Comanthus parvicirrus, the soft corals Sarcophyton sp. nov. and Sinularia sp., and the gorgonian Subergorgia sp. after an initial screening of 266 extracts from different marine origins. Results obtained show that selected purified compounds had a cytotoxic effect on the human leukaemia cell line K562, inhibited both TNF-alpha-induced NF-kappaB-DNA binding as well as TNF-alpha-induced IkappaBalpha degradation and nuclear translocation of p50/p65. Furthermore, we observed the inhibition of NF-kappaB activation induced by an overexpression of IKKbeta. Interestingly, natural products inhibited IKKbeta kinase as well as the 26S proteasome proteolytic activity.