- An integrated method for simultaneously determining 10 classes of per- and polyfluoroalkyl substances in one drop of human serum.
An integrated method for simultaneously determining 10 classes of per- and polyfluoroalkyl substances in one drop of human serum.
Analytica chimica acta (2017-12-20)
Ke Gao, Jianjie Fu, Qiao Xue, Yili Li, Yong Liang, Yuanyuan Pan, Aiqian Zhang, Guibin Jiang
PMID29254577
ABSTRACT
Per- and polyfluoroalkyl substances (PFASs) represent a group of synthetic chemicals, and they have quite different physicochemical properties, which result in difficulties of their simultaneous determination in a single injection. A sensitive, reliable, and fully automated method was developed for simultaneously detecting 10 classes of PFASs (total of 43) in human serum using online Turboflow SPE-UHPLC-MS/MS. This method provided high linearity of matrix-matched calibration standards (R > 0.99), excellent method limits of detection (MLODs) (0.013-0.089 ng mL