- Diastereoselective palladium-catalyzed alpha-arylation of 4-substituted cyclohexyl esters.
Diastereoselective palladium-catalyzed alpha-arylation of 4-substituted cyclohexyl esters.
Organic letters (2008-10-29)
Eric A Bercot, Seb Caille, Tracy M Bostick, Krishnakumar Ranganathan, Randy Jensen, Margaret M Faul
PMID18954065
ABSTRACT
A diastereoselective palladium-catalyzed arylation of 4-substituted cyclohexyl esters has been developed. The reaction proceeds at room temperature in the presence of [(t-Bu3P)PdBr]2 providing products in up to 37:1 dr.