- MSA prions exhibit remarkable stability and resistance to inactivation.
MSA prions exhibit remarkable stability and resistance to inactivation.
Acta neuropathologica (2017-08-30)
Amanda L Woerman, Sabeen A Kazmi, Smita Patel, Yevgeniy Freyman, Abby Oehler, Atsushi Aoyagi, Daniel A Mordes, Glenda M Halliday, Lefkos T Middleton, Steve M Gentleman, Steven H Olson, Stanley B Prusiner
PMID28849371
ABSTRACT
In multiple system atrophy (MSA), progressive neurodegeneration results from the protein α-synuclein misfolding into a self-templating prion conformation that spreads throughout the brain. MSA prions are transmissible to transgenic (Tg) mice expressing mutated human α-synuclein (TgM83
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