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  • Loss of Endometrial Sodium Glucose Cotransporter SGLT1 is Detrimental to Embryo Survival and Fetal Growth in Pregnancy.

Loss of Endometrial Sodium Glucose Cotransporter SGLT1 is Detrimental to Embryo Survival and Fetal Growth in Pregnancy.

Scientific reports (2017-10-05)
Madhuri S Salker, Yogesh Singh, Ni Zeng, Hong Chen, Shaqiu Zhang, Anja T Umbach, Hajar Fakhri, Ursula Kohlhofer, Leticia Quintanilla-Martinez, Ruban R Peter Durairaj, Flavio S V Barros, Pavle Vrljicak, Sascha Ott, Sara Y Brucker, Diethelm Wallwiener, Ivana Vrhovac Madunić, Davorka Breljak, Ivan Sabolić, Hermann Koepsell, Jan J Brosens, Florian Lang
PMID28974690
ABSTRACT

Embryo implantation requires a hospitable uterine environment. A key metabolic change that occurs during the peri-implantation period, and throughout early pregnancy, is the rise in endometrial glycogen content. Glycogen accumulation requires prior cellular uptake of glucose. Here we show that both human and murine endometrial epithelial cells express the high affinity Na