Peptide dendrimer-conjugates of ketoprofen: Synthesis and ex vivo and in vivo evaluations of passive diffusion, sonophoresis and iontophoresis for skin delivery.

Peptide dendrimer-conjugates of ketoprofen: Synthesis and ex vivo and in vivo evaluations of passive diffusion, sonophoresis and iontophoresis for skin delivery.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (2017-03-13)

Aswathi R Hegde, Prarthana V Rewatkar, Jyothsna Manikkath, Karnaker Tupally, Harendra S Parekh, Srinivas Mutalik

ABSTRACT

The aim of this study was to evaluate skin delivery of ketoprofen when covalently tethered to mildly cationic (2

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Fmoc-Lys(Fmoc)-OH, ≥98.0% (HPLC)

Sigma-Aldrich

Triisopropylsilane, 98%

Sigma-Aldrich

HBTU, ≥98.0% (T)