- Diclofenac sodium ion exchange resin complex loaded melt cast films for sustained release ocular delivery.
Diclofenac sodium ion exchange resin complex loaded melt cast films for sustained release ocular delivery.
Drug delivery (2017-02-07)
Goutham R Adelli, Sai Prachetan Balguri, Prakash Bhagav, Vijayasankar Raman, Soumyajit Majumdar
PMID28165833
ABSTRACT
The goal of the present study is to develop polymeric matrix films loaded with a combination of free diclofenac sodium (DFS Effect of ratio of DFS and IR on the DFS:IR complexation efficiency was studied using batch processing. DFS:IR complex, DFS Complexation efficiency of DFS:IR was found to be 99% with a 1:1 ratio of DFS:IR. DFS release from DFS:IR suspension and the film were best-fit to a Higuchi model. In vitro transcorneal flux with the DFS DFS