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  • gem-Difluorination of 2,2-diaryl-1,3-dithiolanes by Selectfluor and pyridinium polyhydrogen fluoride.

gem-Difluorination of 2,2-diaryl-1,3-dithiolanes by Selectfluor and pyridinium polyhydrogen fluoride.

Chemical communications (Cambridge, England) (2005-01-27)
V Prakash Reddy, Ramesh Alleti, Meher K Perambuduru, Urs Welz-Biermann, Herwig Buchholz, G K Surya Prakash
ABSTRACT

2,2-diaryl-1,3-dithiolanes, readily obtainable from diaryl ketones, were transformed into the corresponding gem-difluoro compounds using a novel reagent combination involving Selectfluor and pyridinium polyhydrogen fluoride (PPHF) under mild conditions in moderate to good yields.

MATERIALS
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Product Description

Sigma-Aldrich
Hydrogen fluoride pyridine, pyridine ~30 %, hydrogen fluoride ~70 %