- Aryl urea analogs with broad-spectrum antibacterial activity.
Aryl urea analogs with broad-spectrum antibacterial activity.
Bioorganic & medicinal chemistry letters (2004-10-16)
Punit P Seth, Ray Ranken, Dale E Robinson, Stephen A Osgood, Lisa M Risen, Elizabeth L Rodgers, Michael T Migawa, Elizabeth A Jefferson, Eric E Swayze
PMID15482926
ABSTRACT
The preparation and evaluation of novel aryl urea analogs as broad-spectrum antibacterial agents is described. Numerous compounds showed low micromolar minimum inhibitory concentrations (MIC) against both Gram-positive and Gram-negative bacteria. Selected analogs also exhibited in vivo efficacy in a lethal murine model of bacterial septicemia.
MATERIALS