Iron oxide nanoparticles for magnetically-guided and magnetically-responsive drug delivery.

Iron oxide nanoparticles for magnetically-guided and magnetically-responsive drug delivery.

International journal of molecular sciences (2015-04-14)

Joan Estelrich, Elvira Escribano, Josep Queralt, Maria Antònia Busquets

ABSTRACT

In this review, we discuss the recent advances in and problems with the use of magnetically-guided and magnetically-responsive nanoparticles in drug delivery and magnetofection. In magnetically-guided nanoparticles, a constant external magnetic field is used to transport magnetic nanoparticles loaded with drugs to a specific site within the body or to increase the transfection capacity. Magnetofection is the delivery of nucleic acids under the influence of a magnetic field acting on nucleic acid vectors that are associated with magnetic nanoparticles. In magnetically-responsive nanoparticles, magnetic nanoparticles are encapsulated or embedded in a larger colloidal structure that carries a drug. In this last case, an alternating magnetic field can modify the structure of the colloid, thereby providing spatial and temporal control over drug release.

MATERIALS

Product Number

Brand

Product Description

900034

Sigma-Aldrich

Iron oxide (II,III), nanopowder, 25 nm, NHS ester functionalized

900026

Sigma-Aldrich

Iron oxide (II,III), nanoparticles, 15 nm avg. part. size (TEM), PEG functionalized, 1 mg/mL in H₂O

900062

Sigma-Aldrich

Iron oxide (II,III), nanoparticles, 30 nm avg. part. size (TEM), 5 mg/mL in H₂O

900064

Sigma-Aldrich

Iron oxide (II,III), nanoparticles, 25 nm avg. part. size (TEM), 5 mg/mL in toluene

900043

Sigma-Aldrich

Iron oxide (II,III), nanoparticles, 15 nm avg. part. size (TEM), 5 mg/mL in H₂O

900091

Sigma-Aldrich

Iron oxide (II,III), nanoparticles, 10 nm avg. part. size (TEM), streptavidin functionalized, 1 mg/mL in H₂O

900092

Sigma-Aldrich

Iron oxide (II,III), nanoparticles, 15 nm avg. part. size (TEM), streptavidin functionalized, 1 mg/mL in H₂O

900200

Sigma-Aldrich

Iron oxide (II,III), nanoparticles, 15 nm avg. part. size (TEM), carboxylic acid functionalized, 5 mg/mL in H₂O

900084

Sigma-Aldrich

Iron oxide (II,III), nanoparticles, 10 nm avg. part. size (TEM), 5 mg/mL in chloroform

900148

Sigma-Aldrich

Iron oxide (II,III), nanoparticles, 30 nm avg. part. size (TEM), streptavidin functionalized, 1 mg/mL in H₂O

900088

Sigma-Aldrich

Iron oxide (II,III), nanoparticles, 20 nm avg. part. size (TEM), 5 mg/mL in chloroform

900042

Sigma-Aldrich

Iron oxide (II,III), nanoparticles, 25 nm avg. part. size (TEM), 5 mg/mL in H₂O