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  • SLC41A1 is the only magnesium responsive gene significantly overexpressed in placentas of preeclamptic women.

SLC41A1 is the only magnesium responsive gene significantly overexpressed in placentas of preeclamptic women.

Hypertension in pregnancy (2013-07-13)
Martin Kolisek, Carlos Galaviz-Hernández, Fernando Vázquez-Alaniz, Gerhard Sponder, Saba Javaid, Katharina Kurth, Axel Nestler, Martha Rodríguez-Moran, Stefan Verlohren, Fernando Guerrero-Romero, Jörg Rudolf Aschenbach, Jürgen Vormann
PMID23844728
ABSTRACT

To examine expression profile of magnesium responsive genes (MRGs) in placentas of normoevolutive and preeclamptic women. The expression profiles of MRGs were determined in placentas of normoevolutive (N=26) and preeclamptic (N=25) women by RT-qPCR. Among all tested MRGs (9) only SLC41A1 (encoding for Na(+)/Mg(2+) exchanger) was significantly overexpressed in ~54.2% of preeclamptic (n=24) and in ~9.5% of normoevolutive (n=21) specimens. On average, SLC41A1 was overexpressed sixfold in the preeclamptic group. Presence of SLC41A1 in placentas was confirmed by Western blot analysis. CONCLUSION. SLC41A1 is significantly overexpressed in nearly 55% of preeclamptic placentas. This may indicate a direct contribution of changed Mg homeostasis in the development of preeclampsia.