- Carcinogenicity in rats of the mutagenic compounds 1-nitropyrene and 3-nitrofluoranthene.
Carcinogenicity in rats of the mutagenic compounds 1-nitropyrene and 3-nitrofluoranthene.
Cancer letters (1982-01-01)
H Ohgaki, N Matsukura, K Morino, T Kawachi, T Sugimura, K Morita, H Tokiwa, T Hirota
PMID6277471
ABSTRACT
1-Nitropyrene and 3-nitrofluoranthene are present in diesel exhaust, in pollutants in air, and were also present in certain xerographic toners and copies. Their carcinogenicities were studied in male F344/DuCrj rats by subcutaneous injection. Sarcomas, mainly malignant fibrous histiocytomas at the site of injection were induced in 8 to 17 (47%) rats by 1-nitropyrene and in 4 of 10 (40%) rats by 3-nitrofluoranthene. Some tumors were serially transplantable in the same strain of rats.
MATERIALS