- Efficient base catalyzed alkylation reactions with aziridine electrophiles.
Efficient base catalyzed alkylation reactions with aziridine electrophiles.
Chemical communications (Cambridge, England) (2008-05-21)
Thomas A Moss, Aurelie Alba, David Hepworth, Darren J Dixon
PMID18491019
ABSTRACT
N-Mesitylene sulfonyl and N-tosyl aziridines have been identified as effective electrophiles in alkylation reactions of carbon acids catalyzed by the organic phosphorine base BEMP; yields of up to 99% for a range of pro-nucleophiles under mild reaction conditions are reported.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
2-tert-Butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine, purum, ≥98.0% (GC)