- Enantioselective Reduction of Prochiral Ketones using Spiroborate Esters as Catalysts.
Enantioselective Reduction of Prochiral Ketones using Spiroborate Esters as Catalysts.
Tetrahedron letters (2007-08-13)
Viatcheslav Stepanenko, Melvin De Jesus, Wildeliz Correa, Irisbel Guzman, Cindybeth Vazquez, Wilanet de la Cruz, Margarita Ortiz-Marciales, Charles L Barnes
PMID19554205
ABSTRACT
Novel spiroborate esters derived nonracemic 1,2-aminoalcohols and ethylene glycol are reported as highly effective catalysts for the asymmetric borane reduction of a variety of prochiral ketones with borane-dimethyl sulfide complex at room temperature. Optically active alcohols were obtained in excellent chemical yields using 0.1 to 10 mol % of catalysts with up to 99% ee.
MATERIALS
Product Number
Brand
Product Description