Skip to Content
Merck
CN

A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'.

FEBS letters (2005-09-03)
Frank J Gunn-Moore, Gavin I Welsh, Lissa R Herron, Frances Brannigan, Kanamarlapudi Venkateswarlu, Stewart Gillespie, Margaret Brandwein-Gensler, Rashna Madan, Jeremy M Tavaré, Peter J Brophy, Michael B Prystowsky, Simon Guild
PMID16137681
ABSTRACT

The 4.1 superfamily of proteins contain a 4.1 Ezrin Radixin Moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin. Willin has a recognizable FERM domain within its N-terminus and is capable of binding phospholipids. Its intra-cellular distribution can be cytoplasmic or at the plasma membrane where it can co-localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor.