XRCC3 Thr241Met polymorphism and clinical outcomes of NSCLC patients receiving platinum-based chemotherapy: a systematic review and meta-analysis.

XRCC3 Thr241Met polymorphism and clinical outcomes of NSCLC patients receiving platinum-based chemotherapy: a systematic review and meta-analysis.

PloS one (2013-08-14)

Xiao-yong Shen, Fan-zhen Lu, Yun Wu, Li-ting Zhao, Zhi-feng Lin

ABSTRACT

X-ray repair cross-complementing protein 3 (XRCC3) is an essential gene involved in the double-strand break repair pathway. Published evidence has shown controversial results about the relationship between XRCC3 Thr241Met polymorphism and clinical outcomes of non-small cell lung cancer (NSCLC) patients receiving platinum-based chemotherapy. A systematic review and meta-analysis was performed to evaluate the predictive value of XRCC3 Thr241Met polymorphism on clinical outcomes of advanced NSCLC receiving platinum-based chemotherapy. Response to chemotherapy, overall survival (OS) and progression-free survival (PFS) were analyzed. A number of 11 eligible studies were identified according to the inclusion criteria. Carriers of the variant XRCC3 241Met allele were significantly associated with good response to platinum-based chemotherapy (ThrMet/MetMet vs. ThrThr: OR = 1.509, 95% CI: 1.099-2.072, Pheterogeneity = 0.618). The XRCC3 Thr241Met polymorphism was not associated with OS (MetMet vs. ThrThr, HR = 0.939, 95% CI:0.651-1.356, Pheterogeneity = 0.112) or PFS (MetMet vs. ThrThr, HR = 0.960, 95% CI: 0.539-1.710, Pheterogeneity = 0.198). Additionally, no evidence of publication bias was observed. This systematic review and meta-analysis shows that carriers of the XRCC3 241Met allele are associated with good response to platinum-based chemotherapy in advanced NSCLC, while the XRCC3 Thr241Met polymorphism is not associated with OS or PFS.

MATERIALS

Product Number

Brand

Product Description

520780

Sigma-Aldrich

Platinum black, fuel cell grade, ≥99.9% trace metals basis

520799

Sigma-Aldrich

Platinum black, low bulk density, ≥99.9% trace metals basis

205915

Sigma-Aldrich

Platinum black, black, powder, ≤20 μm, ≥99.95% trace metals basis

GF00716149

Platinum, wire reel, 2m, diameter 0.3mm, as drawn, may be used as one component of a thermocouple, 99.99%

GF43583283

Platinum, wire reel, 1m, diameter 0.04mm, annealed, may be used as one component of a thermocouple, 99.99%

GF41718258

Platinum, wire reel, 5m, diameter 0.05mm, hard, 99.99%

GF36078509

Platinum, wire reel, 5m, diameter 0.1mm, hard, 99.99%

GF16313723

Platinum, wire reel, 1m, diameter 0.002mm, wollaston, 99.9%

GF21655504

Platinum, wire reel, 5m, diameter 0.063mm, hard, 99.9%

444685

Sigma-Aldrich

Platinum, wire, diam. 2.0 mm, 99.9% trace metals basis

267244

Sigma-Aldrich

Platinum, foil, thickness 0.025 mm, 99.9% trace metals basis

GF35358914

Platinum, insulated wire, 2m, conductor diameter 0.025mm, insulation thickness 0.005mm, polyimide insulation, 99.99%

GF21472141

Platinum, rod, 10mm, diameter 4.0mm, 99.95%

GF43344581

Platinum, insulated wire, 2m, conductor diameter 0.018mm, insulation thickness 0.002mm, polyester insulation, 99.99%

GF68710484

Platinum, insulated wire, 0.5m, conductor diameter 0.025mm, insulation thickness 0.001mm, PTFE (polytetrafluoroethylene) insulation, 99.999%

GF41858309

Platinum, foil, 0.2m coil, thickness 0.05mm, coil width 1mm, as rolled, 99.99%

GF60675442

Platinum, foil, 8mm disks, thickness 0.05mm, as rolled, 99.95%

GF25487387

Platinum, wire reel, 0.2m, diameter 1.0mm, hard, 99.95%

GF60594442

Platinum, foil, 0.5m coil, thickness 0.025mm, coil width 8mm, as rolled, 99.95%

GF69099610

Platinum, foil, light tested, 50x50mm, thickness 0.05mm, as rolled, 99.95%

GF36280021

Platinum, foil, 0.2m coil, thickness 0.025mm, coil width .4mm, as rolled, 99.95%

GF09436619

Platinum, tube, 200mm, outside diameter 0.95mm, inside diameter 0.60mm, wall thickness 0.175mm, as drawn, 99.95%

GF71546429

Platinum, rod, 25mm, diameter 1.0mm, 99.95%

GF94661657

Platinum, tube, 200mm, outside diameter 1.2mm, inside diameter 1.0mm, wall thickness 0.1mm, as drawn, 99.95%

GF91208909

Platinum, microfoil, disks, 25mm, thinness 0.1μm, specific density 120μg/cm², permanent mylar 3.5μm support, 99.99%

GF58198517

Platinum, wire reel, 0.05m, diameter 0.6mm, as drawn, 99.99+%

GF26290313

Platinum, tube, 50mm, outside diameter 2.0mm, inside diameter 1.6mm, wall thickness 0.2mm, as drawn, 99.95%

GF85654019

Platinum, foil, 8mm disks, thickness 0.005mm, as rolled, 99.95%

GF72261312

Platinum, insulated wire, 1m, conductor diameter 0.05mm, insulation thickness 0.0075mm, polyester insulation, 99.99%

GF60973791

Platinum, tube, 200mm, outside diameter 1.0mm, inside diameter 0.8mm, wall thickness 0.1mm, as drawn, 99.95%