Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Cancer letters (2012-10-04)

Himashinie V K Diyabalanage, Michael L Granda, Jacob M Hooker

ABSTRACT

One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in vivo in recent studies for many cancer types and stages. In this review, we discuss the most commonly used combinations of histone deacetylase inhibitors and platinum based drugs in the context of their possible mechanisms, efficiency, efficacy, and related drawbacks in preclinical and clinical studies.

MATERIALS

Product Number

Brand

Product Description

520799

Sigma-Aldrich

Platinum black, low bulk density, ≥99.9% trace metals basis

205915

Sigma-Aldrich

Platinum black, black, powder, ≤20 μm, ≥99.95% trace metals basis

520780

Sigma-Aldrich

Platinum black, fuel cell grade, ≥99.9% trace metals basis

GF37854265

Platinum, wire reel, 0.5m, diameter 0.125mm, annealed, may be used as one component of a thermocouple, 99.99%

GF35898924

Platinum, wire reel, 0.2m, diameter 0.25mm, hard, 99.95%

GF45803897

Platinum, wire reel, 0.1m, diameter 1.0mm, hard, 99.95%

GF61547632

Platinum, foil, 8mm disks, thickness 0.01mm, as rolled, 99.95%

GF06440048

Platinum, foil, 4mm disks, thickness 0.05mm, as rolled, 99.95%

GF64750305

Platinum, wire reel, 0.2m, diameter 0.01mm, wollaston, 99.9%

GF04529538

Platinum, foil, 50x50mm, thickness 0.125mm, as rolled, 99.99+%

GF43907799

Platinum, foil, 15mm disks, thickness 0.005mm, as rolled, 99.95%

GF30684540

Platinum, foil, not light tested, 25x25mm, thickness 0.004mm, as rolled, 99.95%

GF23360240

Platinum, wire reel, 0.5m, diameter 0.3mm, annealed, may be used as one component of a thermocouple, 99.99%

GF03383704

Platinum, wire reel, 0.1m, diameter 0.25mm, annealed, may be used as one component of a thermocouple, 99.99%

GF13420257

Platinum, foil, 0.5m coil, thickness 0.025mm, coil width 5mm, as rolled, 99.95%

GF80394914

Platinum, wire reel, 0.5m, diameter 0.5mm, as drawn, 99.99+%

GF47354508

Platinum, wire reel, 0.1m, diameter 0.20mm, annealed, may be used as one component of a thermocouple, 99.99%

GF84594897

Platinum, wire reel, 0.5m, diameter 0.125mm, as drawn, 99.95%

GF62037772

Platinum, wire reel, 1m, diameter 0.0125mm, hard, 99.9%

GF93729134

Platinum, wire reel, 5m, diameter 0.02mm, as drawn, 99.9%

GF12344677

Platinum, foil, not light tested, 50x50mm, thickness 0.0015mm, as rolled, 99.95%

GF96551354

Platinum, foil, 10mm disks, thickness 0.0075mm, as rolled, 99.95%

GF95421450

Platinum, foil, not light tested, 100x100mm, thickness 0.01mm, as rolled, 99.95%

GF11448840

Platinum, foil, 8mm disks, thickness 0.025mm, as rolled, 99.95%

GF87686173

Platinum, foil, 30x30mm, thickness 0.2mm, as rolled, 99.95%

GF19578831

Platinum, wire reel, 0.05m, diameter 0.20mm, annealed, may be used as one component of a thermocouple, 99.99%

GF15087203

Platinum, foil, 0.1m coil, thickness 0.025mm, coil width 1.6mm, as rolled, 99.95%

GF03272868

Platinum, foil, 4mm disks, thickness 0.125mm, as rolled, 99.95%

GF00187163

Platinum, foil, 0.1m coil, thickness 0.15mm, coil width .9mm, as rolled, 99.99%

GF85632408

Platinum, foil, 6mm disks, thickness 0.025mm, as rolled, 99.99+%