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  • Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Journal of inorganic biochemistry (2012-07-24)
A G Quiroga
ABSTRACT

This focused review is devoted to our advances in developing trans platinum complexes as antitumoral complexes, in particular those bearing aliphatic amines. It includes some fundamental aspects of the understanding of non conventional metallodrug mechanism. The perspective is arranged by those fundamental aspects and within each section only the most successful examples have been included and also those in which clearly SAR's (structure activity relationships) have been observed.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Platinum black, low bulk density, ≥99.9% trace metals basis
Sigma-Aldrich
Platinum black, black, powder, ≤20 μm, ≥99.95% trace metals basis
Sigma-Aldrich
Platinum black, fuel cell grade, ≥99.9% trace metals basis
Platinum, wire reel, 0.5m, diameter 0.125mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, wire reel, 0.2m, diameter 0.25mm, hard, 99.95%
Platinum, wire reel, 0.1m, diameter 1.0mm, hard, 99.95%
Platinum, foil, 8mm disks, thickness 0.01mm, as rolled, 99.95%
Platinum, foil, 4mm disks, thickness 0.05mm, as rolled, 99.95%
Platinum, wire reel, 0.2m, diameter 0.01mm, wollaston, 99.9%
Platinum, foil, 50x50mm, thickness 0.125mm, as rolled, 99.99+%
Platinum, foil, 15mm disks, thickness 0.005mm, as rolled, 99.95%
Platinum, foil, not light tested, 25x25mm, thickness 0.004mm, as rolled, 99.95%
Platinum, wire reel, 0.5m, diameter 0.3mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, wire reel, 0.1m, diameter 0.25mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, foil, 0.5m coil, thickness 0.025mm, coil width 5mm, as rolled, 99.95%
Platinum, wire reel, 0.5m, diameter 0.5mm, as drawn, 99.99+%
Platinum, wire reel, 0.1m, diameter 0.20mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, wire reel, 0.5m, diameter 0.125mm, as drawn, 99.95%
Platinum, wire reel, 1m, diameter 0.0125mm, hard, 99.9%
Platinum, wire reel, 5m, diameter 0.02mm, as drawn, 99.9%
Platinum, foil, not light tested, 50x50mm, thickness 0.0015mm, as rolled, 99.95%
Platinum, foil, 10mm disks, thickness 0.0075mm, as rolled, 99.95%
Platinum, foil, not light tested, 100x100mm, thickness 0.01mm, as rolled, 99.95%
Platinum, foil, 8mm disks, thickness 0.025mm, as rolled, 99.95%
Platinum, foil, 30x30mm, thickness 0.2mm, as rolled, 99.95%
Platinum, wire reel, 0.05m, diameter 0.20mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, foil, 0.1m coil, thickness 0.025mm, coil width 1.6mm, as rolled, 99.95%
Platinum, foil, 4mm disks, thickness 0.125mm, as rolled, 99.95%
Platinum, foil, 0.1m coil, thickness 0.15mm, coil width .9mm, as rolled, 99.99%
Platinum, foil, 6mm disks, thickness 0.025mm, as rolled, 99.99+%