Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Journal of inorganic biochemistry (2012-07-24)

A G Quiroga

PMID22819649

ABSTRACT

This focused review is devoted to our advances in developing trans platinum complexes as antitumoral complexes, in particular those bearing aliphatic amines. It includes some fundamental aspects of the understanding of non conventional metallodrug mechanism. The perspective is arranged by those fundamental aspects and within each section only the most successful examples have been included and also those in which clearly SAR's (structure activity relationships) have been observed.

MATERIALS

Product Number

Brand

Product Description

520799

Sigma-Aldrich

Platinum black, low bulk density, ≥99.9% trace metals basis

349380

Sigma-Aldrich

Platinum, foil, thickness 0.1 mm, 99.9% trace metals basis

444685

Sigma-Aldrich

Platinum, wire, diam. 2.0 mm, 99.9% trace metals basis

349348

Sigma-Aldrich

Platinum, foil, thickness 0.127 mm, 99.99% trace metals basis

349321

Sigma-Aldrich

Platinum, foil, thickness 0.25 mm, 99.99% trace metals basis

327484

Sigma-Aldrich

Platinum, shot, ≤3 mm, ≥99.9% trace metals basis

357375

Sigma-Aldrich

Platinum, wire, diam. 0.076 mm, ≥99.99% trace metals basis

267821

Sigma-Aldrich

Platinum, wire, diam. 0.127 mm, 99.9% trace metals basis

298093

Sigma-Aldrich

Platinum, gauze, 100 mesh, 99.9% trace metals basis

GF78892981

Platinum, wire reel, 0.05m, diameter 0.8mm, annealed, may be used as one component of a thermocouple, 99.99%

267244

Sigma-Aldrich

Platinum, foil, thickness 0.025 mm, 99.9% trace metals basis

349402

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, 99.9% trace metals basis

GF59918912

Platinum, wire, straight, 100mm, diameter 0.1mm, hard, 99.99%

520780

Sigma-Aldrich

Platinum black, ≥99.9% trace metals basis

GF58265488

Platinum, foil, not light tested, 50x50mm, thickness 0.004mm, as rolled, 99.95%

GF57762399

Platinum, foil, not light tested, 50x50mm, thickness 0.005mm, as rolled, 99.95%

GF95639901

Platinum, wire reel, 1m, diameter 0.40mm, as drawn, 99.99%

GF29339286

Platinum, wire reel, 1m, diameter 0.01mm, hard, 99.9%

GF51981026

Platinum, wire reel, 2m, diameter 0.04mm, annealed, may be used as one component of a thermocouple, 99.99%

GF85887545

Platinum, wire reel, 1m, diameter 0.15mm, annealed, may be used as one component of a thermocouple, 99.99%

GF74437656

Platinum, wire reel, 1m, diameter 0.5mm, annealed, may be used as one component of a thermocouple, 99.99%

GF15145286

Platinum, wire reel, 1m, diameter 0.025mm, annealed, may be used as one component of a thermocouple, 99.99%

GF41572414

Platinum, foil, 8mm disks, thickness 0.0075mm, as rolled, 99.95%

GF89210336

Platinum, foil, 4mm disks, thickness 0.025mm, as rolled, 99.95%

GF04051178

Platinum, foil, 8mm disks, thickness 0.025mm, as rolled, 99.99+%

771937

Sigma-Aldrich

Platinum, nanopowder, 200 nm particle size (SEM), 99.9% (metals basis)

GF45591981

Platinum, wire reel, 1m, diameter 0.175mm, as drawn, 99.95%

GF35942632

Platinum, wire reel, 2m, diameter 0.15mm, annealed, may be used as one component of a thermocouple, 99.99%

GF85549832

Platinum, wire reel, 1m, diameter 0.02mm, as drawn, 99.9%

GF95233710

Platinum, wire reel, 2m, diameter 0.25mm, hard, 99.95%