Recent advances in bioinorganic chemistry of bismuth.

Recent advances in bioinorganic chemistry of bismuth.

Current opinion in chemical biology (2012-02-11)

Hongyan Li, Hongzhe Sun

ABSTRACT

Bismuth has been used in medicine for over two centuries for the treatment of various diseases, in particular for gastrointestinal disorders, owing to its antimicrobial activity. Recent structural characterization of bismuth drugs provides an insight into assembly and pharmacokinetic pathway of the drugs. Mining potential protein targets inside the pathogen via metallomic/metalloproteomic approach and further characterization on the interactions of bismuth drugs with these targets laid foundation in understanding the mechanism of action of bismuth drugs. Such studies would be beneficial in rational design of new potential drugs.

MATERIALS

Product Number

Brand

Product Description

556130

Sigma-Aldrich

Bismuth, pieces, 1-12 mm, 99.999% trace metals basis

264008

Sigma-Aldrich

Bismuth, powder, −100 mesh, ≥99.99% trace metals basis

265462

Sigma-Aldrich

Bismuth, powder, −100 mesh, 99% trace metals basis

265470

Sigma-Aldrich

Bismuth, shot, 4-30 mesh, 99.9% trace metals basis

GF50591268

Bismuth, foil, not light tested, 25x25mm, thickness 0.005mm, permanent polyester support, 99.97%

GF82117447

Bismuth, foil, not light tested, 50x50mm, thickness 0.001mm, permanent polyester support, 99.97%

GF09816307

Bismuth, foil, light tested, 50x50mm, thickness 0.02mm, permanent polyester support, 99.97%

452386

Sigma-Aldrich

Bismuth, beads, 1-5 mm, 99.999% trace metals basis

GF10746862

Bismuth, foil, not light tested, 150x150mm, thickness 0.02mm, permanent polyester support, 99.97%

GF35246831

Bismuth, foil, light tested, 25x25mm, thickness 0.02mm, permanent polyester support, 99.97%

GF12228465

Bismuth, foil, not light tested, 25x25mm, thickness 0.0025mm, permanent polyester support, 99.97%

GF95571995

Bismuth, foil, light tested, 25x25mm, thickness 0.05mm, permanent polyester support, 99.97%

GF91446947

Bismuth, foil, not light tested, 25x25mm, thickness 0.002mm, permanent polyester support, 99.97%

GF75246183

Bismuth, foil, 50x50mm, thickness 2.0mm, 100%

GF71673060

Bismuth, foil, light tested, 50x50mm, thickness 0.025mm, permanent polyester support, 99.97%

GF64303455

Bismuth, foil, not light tested, 100x100mm, thickness 0.05mm, permanent polyester support, 99.97%

GF40931546

Bismuth, foil, light tested, 25x25mm, thickness 0.025mm, permanent polyester support, 99.97%

GF51459217

Bismuth, foil, not light tested, 50x50mm, thickness 0.0025mm, permanent polyester support, 99.97%

GF24083692

Bismuth, foil, not light tested, 100x100mm, thickness 0.015mm, permanent polyester support, 99.97%

GF60515850

Bismuth, foil, not light tested, 50x50mm, thickness 0.002mm, permanent polyester support, 99.97%

GF39813419

Bismuth, foil, 50x50mm, thickness 0.25mm, 100%

GF12550935

Bismuth, foil, light tested, 50x50mm, thickness 0.015mm, permanent polyester support, 99.97%

GF19216087

Bismuth, foil, not light tested, 100x100mm, thickness 0.02mm, permanent polyester support, 99.97%

GF89918500

Bismuth, foil, 25x25mm, thickness 0.25mm, 100%

GF53868718

Bismuth, foil, not light tested, 50x50mm, thickness 0.015mm, permanent polyester support, 99.97%

GF86561354

Bismuth, foil, not light tested, 50x50mm, thickness 0.025mm, permanent polyester support, 99.97%

GF85045631

Bismuth, foil, not light tested, 50x50mm, thickness 0.01mm, permanent polyester support, 99.97%

GF93912891

Bismuth, foil, not light tested, 100x100mm, thickness 0.025mm, permanent polyester support, 99.97%

GF09655263

Bismuth, foil, light tested, 50x50mm, thickness 0.01mm, permanent polyester support, 99.97%

GF86892441

Bismuth, foil, light tested, 25x25mm, thickness 0.01mm, permanent polyester support, 99.97%