Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease.

Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease.

Journal of inorganic biochemistry (2011-11-22)

Maire E Percy, Theo P A Kruck, Aileen I Pogue, Walter J Lukiw

PMID22099160

ABSTRACT

In 1991, treatment with low dose intramuscular desferrioxamine (DFO), a trivalent chelator that can remove excessive iron and/or aluminum from the body, was reported to slow the progression of Alzheimer's disease (AD) by a factor of two. Twenty years later this promising trial has not been followed up and why this treatment worked still is not clear. In this critical interdisciplinary review, we provide an overview of the complexities of AD and involvement of metal ions, and revisit the neglected DFO trial. We discuss research done by us and others that is helping to explain involvement of metal ion catalyzed production of reactive oxygen species in the pathogenesis of AD, and emerging strategies for inhibition of metal-ion toxicity. Highlighted are insights to be considered in the quests to prevent potentially toxic effects of aluminum toxicity and prevention and intervention in AD.

MATERIALS

Product Number

Brand

Product Description

433705

Sigma-Aldrich

Aluminum, evaporation slug, diam. × L 6.3 mm × 6.3 mm, 99.999% trace metals basis

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Aluminum, sphere, 100pcs, diameter 3.0mm, aluminum alloy 2017 precision sphere, grade 200, 95.2%

733369

Sigma-Aldrich

Aluminum, foil, thickness 8 μm, 99% trace metals basis

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Aluminum, wire reel, 500m, diameter 0.5mm, as drawn, 99.5%

266523

Sigma-Aldrich

Aluminum, ReagentPlus^®, beads, 5-15 mm, 99.9% trace metals basis

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Aluminum, honeycomb, 600x600mm, thickness 26.5mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm³, phenolic adhesive (resin), facing skin carbon fiber / epoxy, 99.9%

GF33400224

Aluminum, honeycomb, 600x600mm, thickness 52.3mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm³, phenolic adhesive (resin), facing skin glass fiber 0.75mm, 99.9%

GF87997000

Aluminum, honeycomb, 300x300mm, thickness 20mm, cell size 4.8mm, cell wall 0.038mm, core density 0.070g/cm³, phenolic adhesive (resin), 99.5%

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Aluminum, honeycomb, 600x600mm, thickness 5mm, cell size 13mm, cell wall 0.1mm, core density 0.062g/cm³, phenolic adhesive (resin), 99.5%

GF23840221

Aluminum, honeycomb, 300x300mm, thickness 26.5mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm³, phenolic adhesive (resin), facing skin aluminum 0.55mm, 99.9%

GF10029596

Aluminum, foam, 150x150mm, thickness 6.35mm, bulk density 0.2g/cm³, porosity 0.93, 8 pores/cm, aluminum 6101 grade, 98.5%

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Aluminum, mesh, 150x150mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh

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Aluminum, rod, 100mm, diameter 6.0mm, as drawn, 99.999%

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Aluminum, sphere, 100pcs, diameter 2.5mm, aluminum alloy 2017 precision sphere, grade 200, 95.2%

GF14437975

Aluminum, tube, 1000mm, outside diameter 0.86mm, inside diameter 0.76mm, wall thickness 0.05mm, as drawn, 99.5%

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Aluminum, rod, 44mm, diameter 77.5mm, as drawn, 99.999%

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Aluminum, wire reel, 100m, diameter 0.063mm, annealed, 99.99%

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Aluminum, rod, 200mm, diameter 20.0mm, as drawn, 99.999%

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Aluminum, tube, 1000mm, outside diameter 1.42mm, inside diameter 1.166mm, wall thickness 0.127mm, as drawn, 99.5%

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Aluminum, rod, 100mm, diameter 12.0mm, as drawn, 99.999%

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Aluminum, wire reel, 1000m, diameter 0.7mm, as drawn, 99.5%

GF93309037

Aluminum, tube, 200mm, outside diameter 1.42mm, inside diameter 1.166mm, wall thickness 0.127mm, as drawn, 99.5%

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Aluminum, rod, 50mm, diameter 28mm, as drawn, 99.999%

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Aluminum, tube, 2m coil, as drawn, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, 99.5%

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Aluminum, rod, 200mm, diameter 10.0mm, as drawn, 99.999%

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Aluminum, rod, 100mm, diameter 12.7mm, 99%

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Aluminum, wire reel, 1000m, diameter 0.30mm, as drawn, 99.5%

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Aluminum, tube, 200mm, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, as drawn, 99.5%

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Aluminum, tube, 1000mm, outside diameter 0.55mm, inside diameter 0.4mm, wall thickness 0.075mm, as drawn, 99.5%

GF21896039

Aluminum, rod, 200mm, diameter 12.0mm, as drawn, 99.999%