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  • Determination of 2,6-dimethyl-4-(2'-nitrosophenyl)-3,5-pyridinedicarboxylic acid dimethylester in nifedipine by derivative UV-spectrophotometry in bulk material and pharmaceutical forms.

Determination of 2,6-dimethyl-4-(2'-nitrosophenyl)-3,5-pyridinedicarboxylic acid dimethylester in nifedipine by derivative UV-spectrophotometry in bulk material and pharmaceutical forms.

Farmaco (Societa chimica italiana : 1989) (1990-06-01)
G Carlucci, A Colanzi, P Mazzeo
ABSTRACT

A method for the determination of 2,6-dimethyl-4-(2'-nitrosophenyl)-3,5-pyridinedicarboxylic acid dimethylester in nifedipine (bulk material and pharmaceutical formulations) by second-derivative ultraviolet spectrophotometry is described. The procedure is simple and rapid and gives accurate and precise results.

MATERIALS
Product Number
Brand
Product Description

USP
Nifedipine Nitrosophenylpyridine Analog, United States Pharmacopeia (USP) Reference Standard
Nifedipine impurity B, European Pharmacopoeia (EP) Reference Standard