- In vitro killing of nosocomial pathogens by acid and acidified nitrite.
In vitro killing of nosocomial pathogens by acid and acidified nitrite.
Antimicrobial agents and chemotherapy (2006-10-27)
Agam Rao, Robin L P Jump, Nicole J Pultz, Michael J Pultz, Curtis J Donskey
PMID17065628
ABSTRACT
Exposure to pH 1 or 2 buffers or acidic gastric contents resulted in the killing of vancomycin-resistant Enterococcus sp., Klebsiella pneumoniae, Staphylococcus aureus, and Candida glabrata but not Clostridium difficile spores. Nitrite enhanced killing under acidic conditions, but significant killing of C. difficile spores required nitrite concentrations above usual physiological levels.
