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  • Silver(I)-catalyzed deprotection of p-methoxybenzyl ethers: a mild and chemoselective method.

Silver(I)-catalyzed deprotection of p-methoxybenzyl ethers: a mild and chemoselective method.

The Journal of organic chemistry (2012-09-26)
Nicolas Kern, Thomas Dombray, Aurélien Blanc, Jean-Marc Weibel, Patrick Pale
ABSTRACT

The p-methoxybenzyl protecting group (PMB) on various alcohols and an acid was efficiently and selectively cleaved by the action of a catalytic amount of silver(I) hexafluoroantimonate combined with 0.5 equiv of 1,3,5-trimethoxybenzene in dichloromethane at 40 °C.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
1,3,5-Trimethoxybenzene, ReagentPlus®, ≥99%