- Synthesis and cytotoxic effect of carbocyclic potential minor groove binders.
Synthesis and cytotoxic effect of carbocyclic potential minor groove binders.
Farmaco (Societa chimica italiana : 1989) (2004-02-28)
Danuta Bartulewicz, Tomasz Anchim, Milena Dabrowska, Krystyna Midura-Nowaczek
PMID14987984
ABSTRACT
New carbocyclic potential minor groove binders were synthesised, using 3-nitrobenzoyl chloride and aliphatic alpha,omega-diamines with three, four and five methylene fragments. The half structures, compounds IV-VI can be compared to bis-amidines, compounds X-XII to bis-netropsin. All of the compounds were investigated antiproliferative and cytotoxic effects in the standard cell line of mammalian tumour MCF-7.
MATERIALS