Skip to Content
Merck
CN
  • Technetium-99m-labeled ceftizoxime loaded long-circulating and pH-sensitive liposomes used to identify osteomyelitis.

Technetium-99m-labeled ceftizoxime loaded long-circulating and pH-sensitive liposomes used to identify osteomyelitis.

Bioorganic & medicinal chemistry letters (2012-06-26)
Soraya Maria Zandim Maciel Dias Ferreira, Giselle Pires Domingos, Diego dos Santos Ferreira, Talita Guieiro Ribeiro Rocha, Rogéria Serakides, Cleuza Maria de Faria Rezende, Valbert Nascimento Cardoso, Simone Odília Antunes Fernandes, Mônica Cristina Oliveira
PMID22726927
ABSTRACT

Osteomyelitis is an infectious disease located in the bone or bone marrow. Long-circulating and pH-sensitive liposomes containing a technetium-99m-labeled antibiotic, ceftizoxime, (SpHL-(99m)Tc-CF) were developed to identify osteomyelitis foci. Biodistribution studies and scintigraphic images of bone infection or non infection-bearing rats that had been treated with these liposomes were performed. A high accumulation in infectious foci and high values in the target-non target ratio could be observed. These results indicate the potential of SpHL-(99m)Tc-CF as a potential agent for the diagnosis of bone infections.