- Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies.
Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (2011-03-01)
T Fujimoto, T Andoh, T Sudo, I Fujita, M Imabori, H Moritake, T Sugimoto, Y Sakuma, T Takeuchi, H Sonobe, Alan L Epstein, T Akisue, M Kirihata, M Kurosaka, Y Fukumori, H Ichikawa
PMID21354804
ABSTRACT
Clear cell sarcoma (CCS), a rare malignant tumor with a predilection for young adults, is of poor prognosis. Recently however, boron neutron capture therapy (BNCT) with the use of p-borono-L-phenylalanine (BPA) for malignant melanoma has provided good results. CCS also produces melanin; therefore, the uptake of BPA is the key to the application of BNCT to CCS. We describe, for the first time, the high accumulation of boron in CCS and the CCS tumor-bearing animal model generated for BNCT studies.
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