- In vivo metabolism of alpha-methyltryptamine in rats: identification of urinary metabolites.
In vivo metabolism of alpha-methyltryptamine in rats: identification of urinary metabolites.
Xenobiotica; the fate of foreign compounds in biological systems (2008-11-05)
T Kanamori, K Kuwayama, K Tsujikawa, H Miyaguchi, Y T Iwata, H Inoue
PMID18982537
ABSTRACT
1. The in vivo metabolism of alpha-methyltryptamine (AMT), a psychoactive tryptamine analogue, was studied in rats. 2. Male Wistar rats were administered 10 mg kg(-1) AMT orally and 24-h urine fractions were collected. After enzymatic hydrolysis of the urine sample, the metabolites were extracted by liquid-liquid extraction and analysed by gas chromatography/mass spectrometry (GC/MS). 3. 2-Oxo-AMT, 6-hydroxy-AMT, 7-hydroxy-AMT and 1'-hydroxy-AMT were detected as metabolites of AMT.