- The effects of radiation and alkylating agents on chromatin degradation in normal and tumour lymphoid cells.
The effects of radiation and alkylating agents on chromatin degradation in normal and tumour lymphoid cells.
General physiology and biophysics (1991-02-01)
N I Ryabchenko, V Jurásková, B P Ivannik, A V Konov, V Drásil
PMID1651271
ABSTRACT
The dynamic of chromatin degradation was studied in thymocytes and LS/BL tumour cells. In permeabilised LS/BL cells, the rate of DNA degradation induced by endogenous calcium and magnesium-dependent endonuclease was approx. 25 times slower than in thymocytes. In LS/BL cells irradiation does not induce chromatin degradation. The alkylating agent TS 160 induced chromatin degradation in both LS/BL lymphosarcoma cells and thymocytes.