- Parallel synthesis of 1,2,4-oxadiazoles using CDI activation.
Parallel synthesis of 1,2,4-oxadiazoles using CDI activation.
Bioorganic & medicinal chemistry letters (1999-02-18)
T L Deegan, T J Nitz, D Cebzanov, D E Pufko, J A Porco
PMID10021930
ABSTRACT
1,2,4-Oxadiazoles have been prepared in parallel using 1,1'-carbonyldiimidazole (CDI) as a reagent for both formation and cyclodehydration of O-acyl benzamidoximes. The use of CDI facilitates parallel purification of the oxadiazole products by simple liquid-liquid extraction and filtration.
MATERIALS