- Reaction kinetics of alkyl epoxides with DNA and other nucleophiles.
Reaction kinetics of alkyl epoxides with DNA and other nucleophiles.
Chemico-biological interactions (1994-10-01)
A Hemminki, T Väyrynen, K Hemminki
PMID8069949
ABSTRACT
1,2-Epoxy alkanes from C3 to C8 were reacted with DNA, deoxyguanosine and 4-(p-nitrobenzyl) pyridine (NBP). DNA was hydrolyzed at neutral pH to release 7-alkylguanines. The products were analyzed by HPLC. The epoxides reacted largely according to the chain length, shorter epoxides being more reactive. Substitutions through carbon 1 predominated. Reactivity with NBP was almost equal between the epoxides.