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  • Asymmetric one-pot sequential Mannich/hydroamination reaction by organo- and gold catalysts: synthesis of spiro[pyrrolidin-3,2'-oxindole] derivatives.

Asymmetric one-pot sequential Mannich/hydroamination reaction by organo- and gold catalysts: synthesis of spiro[pyrrolidin-3,2'-oxindole] derivatives.

Organic letters (2013-04-09)
Xianjie Chen, Hui Chen, Xun Ji, Hualiang Jiang, Zhu-Jun Yao, Hong Liu
PMID23560725
ABSTRACT

An asymmetric organo- and gold-catalyzed one-pot sequential Mannich/hydroamination reaction has been developed. Using this protocol, spiro[pyrrolidin-3,2'-oxindole] derivatives were synthesized in good yields (up to 91%) and excellent enantioselectivities (up to 97% ee).

MATERIALS
Product Number
Brand
Product Description
O9808
Sigma-Aldrich
2-Oxindole, 97%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 mL
Please contact Customer Service for Availability
CN¥449.03
1 L
Available to ship on April 21, 2025
Details...
CN¥1,177.41
CN¥353.23
18 L
Please contact Customer Service for Availability
CN¥7,796.84