Skip to Content
Merck
CN
  • Mutation induction in Chinese hamster lung V79 cells by five alk-2-enals produced by lipid peroxidation.

Mutation induction in Chinese hamster lung V79 cells by five alk-2-enals produced by lipid peroxidation.

Mutation research (1990-06-01)
R Canonero, A Martelli, U M Marinari, G Brambilla
ABSTRACT

Five alk-2-enals--pent-2-enal, hex-2-enal, hept-2-enal, oct-2-enal and non-2-enal--produced by lipid peroxidation were tested for mutagenic activity in V79 Chinese hamster cells. At concentrations ranging from 0.003 to 0.3 mM all 5 alk-2-enals induced a dose-dependent increase in the frequency of 6-thioguanine-resistant mutants, and their mutagenic potency was found to increase with the length of the carbon chain. In contrast, only hept-2-enal produced a statistically significant increase in the number of mutations to ouabain resistance.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
trans-2-Pentenal, 95%
Sigma-Aldrich
trans-2-Pentenal, ≥95%, FG
Sigma-Aldrich
trans-2-Octenal, ≥95%, stabilized, FG
Sigma-Aldrich
trans-2-Octenal, technical grade, 94%
Sigma-Aldrich
trans-2-Heptenal, ≥95%
Sigma-Aldrich
trans-2-Heptenal, ≥95%, stabilized, FG