- Allylation of functionalized aldehydes by potassium allyltrifluoroborate catalyzed by 18-crown-6 in aqueous media.
Allylation of functionalized aldehydes by potassium allyltrifluoroborate catalyzed by 18-crown-6 in aqueous media.
Molecules (Basel, Switzerland) (2012-11-30)
Fernanda C G Barbosa, Juliano C R Freitas, Caio F Melo, Paulo H Menezes, Roberta A Oliveira
PMID23192187
ABSTRACT
An efficient method for the allylation of aldehydes containing a broad range of functional groups using potassium allyltrifluoroborate is described. The reaction utilizes a catalytic amount of 18-C-6 in biphasic media under open atmosphere and room temperature to provide the corresponding homoallylic alcohols in high yields and without the necessity of any subsequent purification.