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  • Nano-sized clusters of a teicoplanin ψ-aglycon-fullerene conjugate. Synthesis, antibacterial activity and aggregation studies.

Nano-sized clusters of a teicoplanin ψ-aglycon-fullerene conjugate. Synthesis, antibacterial activity and aggregation studies.

European journal of medicinal chemistry (2012-07-17)
Szilvia Tollas, Ilona Bereczki, Attila Sipos, Erzsébet Rőth, Gyula Batta, Lajos Daróczi, Sándor Kéki, Eszter Ostorházi, Ferenc Rozgonyi, Pál Herczegh
PMID22795664
ABSTRACT

Glycopeptide antibiotic derivative teicoplanin ψ-aglycone has been bound covalently to a fullerenopyrrolidine derivative using azide-alkyne 1,3-dipolar cycloaddition reaction. The aggregation of the antibiotic-fullerene conjugate in aqueous solution has been studied. The conjugate exhibited antibacterial activity against enterococci resistant to teicoplanin.